Evidence map›Paper›PMID 34747246›Full record

ArticleThe neuroradiology journal2022

Determinants of intracranial aneurysm retreatment following embolization with a single flow-diverting stent.

Justin E Vranic, Pablo Harker, Christopher J Stapleton, Robert W Regenhardt, Adam A Dmytriw, Naif M Alotaibi, Rajiv Gupta, Thabele M Leslie-Mazwi, Matthew J Koch, Scott B Raymond and 10 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The neuroradiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Persistent flow inside the Woven EndoBridge at angiographic follow-up: A multicenter study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Justin E VranicDepartment of Radiology, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.ORCID https://orcid.org/0000-0002-6000-6709
Pablo HarkerDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Christopher J StapletonDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Robert W RegenhardtDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.ORCID https://orcid.org/0000-0003-2958-3484
Adam A DmytriwDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Naif M AlotaibiDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Rajiv GuptaDepartment of Radiology, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Thabele M Leslie-MazwiDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Matthew J KochDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Scott B RaymondDepartment of Radiology, 2090University of Vermont Medical Center, University of Vermont Medical Center, USA.
Justin R MascitelliDepartment of Neurosurgery, University of Texas Health Science Center at San Antonio, Long School of Medicine, USA.
T Tyler PattersonDepartment of Neurosurgery, University of Texas Health Science Center at San Antonio, Long School of Medicine, USA.
Joshua SeinfeldDepartment of Neurosurgery, University of Colorado, USA.
Andrew WhiteDepartment of Neurosurgery, University of Colorado, USA.
David CaseDepartment of Neurosurgery, University of Colorado, USA.
Christopher RoarkDepartment of Neurosurgery, University of Colorado, USA.
Chirag D GandhiDepartment of Neurosurgery, 8138Westchester Medical Center, 8138Westchester Medical Center, USA.
Fawaz Al-MuftiDepartment of Neurosurgery, 8138Westchester Medical Center, 8138Westchester Medical Center, USA.
Jared CooperDepartment of Neurosurgery, 8138Westchester Medical Center, 8138Westchester Medical Center, USA.
Aman B PatelDepartment of Neurosurgery, 2348Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, USA.
Harvard University · USWestchester Medical Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Vermont Medical Center · US

Funding

Neuroscience Resident Research ProgramR25NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, WILLIAMS, ZIV · 2009 to 2023
$11.8M
NINDS NIH HHS R25 NS065743
6 · The paper itself

Abstract

purposeFlow diverting stents have revolutionized the treatment of intracranial aneurysms through endoluminal reconstruction of the parent vessel. Despite this, certain aneurysms require retreatment. The purpose of this study was to identify clinical and radiologic determinants of aneurysm retreatment following flow diversion.

methodsA multicenter flow diversion database was evaluated to identify patients presenting with an unruptured, previously untreated aneurysm with a minimum of 12 months' clinical and angiographic follow-up. Univariate and multivariate logistic regression modeling was performed to identify determinants of retreatment.

resultsWe identified 189 aneurysms treated in 189 patients with a single flow-diverting stent. Mean age was 54 years, and 89% were female. Complete occlusion was achieved in 70.3% and 83.6% of patients at six and 12 months, respectively. Aneurysm retreatment with additional flow-diverting stents occurred in 5.8% of cases. Univariate analysis revealed that dome diameter

conclusionsProlonged DAPT is the most important determinant of aneurysm retreatment following single-device flow diversion. Abbreviating DAPT duration to only six months should be a consideration in this population, especially for patients with a large aneurysm dome diameter.

Indexed as

Embolization, TherapeuticEndovascular ProceduresIntracranial AneurysmFemaleHumansMaleMiddle AgedPlatelet Aggregation InhibitorsRetreatmentRetrospective StudiesStentsTreatment OutcomePlatelet Aggregation InhibitorsAneurysmendovascularflow diversionretreatment

Identifiers

PMID34747246
PMCPMC9437496
OpenAlexW3213622217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.