ArticleAmerican journal of physiology. Renal physiology2022
Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells.
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Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin-induced diabetic mice.Journal of diabetes investigation · 2026Article
- Angiotensin receptor blocker ameliorates the development of tubulointerstitial injury and fibrosis associated with tubular proteinuria observed in subclinical diabetic kidney disease.Frontiers in pharmacology · 2026Article
- Antiproteinuric effect of dapagliflozin attenuates tubule-interstitial injury development in subclinical acute kidney injury animal model.Frontiers in pharmacology · 2026Article
- Downregulation of Akt induces proximal tubule epithelial cell apoptosis via FOXO and BIM pathway in proteinuric States.Scientific reports · 2025Article
- Injured Proximal Tubular Epithelial Cells Lose Hepatocyte Nuclear Factor 4α Expression Crucial for Brush Border Formation and Transport.The American journal of pathology · 2025Article
- Protein handling in kidney tubules.Nature reviews. Nephrology · 2025Review
- Megalin as a Metabolic Modulator in the Kidney and Beyond.Function (Oxford, England) · 2024Article
- Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury.Function (Oxford, England) · 2024Article
- The scaffold protein disabled 2 (DAB2) and its role in tumor development and progression.Molecular biology reports · 2024Review
- SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake.American journal of physiology. Renal physiology · 2024Article
- Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.EJNMMI radiopharmacy and chemistry · 2024Article
- (Zebra)fishing for nephrogenesis genes.Tissue barriers · 2024Review
- Fluid shear stress-induced changes in megalin trafficking enhance endocytic capacity in proximal tubule cells.Frontiers in physiology · 2024Article
- Receptor-associated protein impairs ligand binding to megalin and megalin-dependent endocytic flux in proximal tubule cells.American journal of physiology. Renal physiology · 2023Article
- Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.Molecular biology of the cell · 2023Article
- LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.Cell and tissue research · 2023Article
- Lipocalin 2 receptors: facts, fictions, and myths.Frontiers in immunology · 2023Review
- Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives.International journal of molecular sciences · 2022Review
- Pacsin2 is required for endocytosis in the zebrafish pronephric tubule.Biology open · 2022Article
- Modelling normal and nephrotic axial uptake of albumin and other filtered proteins along the proximal tubule.The Journal of physiology · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Kimberly R LongRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Youssef RbaibiRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Corry D BondiRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
B Rhodes FordDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Amanda C PoholekDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Cary R Boyd-ShiwarskiRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-2350-3052
Roderick J TanRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0003-1012-1722
Joseph D LockerDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ora A WeiszRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0003-2985-4870
University of Pittsburgh · US
Funding
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4MTraining in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2MLung-specific expression and function of Blimp-1 in T cells impacting allergic asthmaR01AI153104 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2025
$2.6MEndocytic Pathway Dysfunction in Dent DiseaseR01DK125049 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISZ, ORA A · 2020 to 2024
$2.3MProximal tubule endocytosis in normal and nephrotic kidneysR01DK118726 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISZ, ORA A · 2019 to 2022
$1.8MThe function of kidney specific (KS)-WNK1 condensates during potassium stressK08DK118211 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYD-SHIWARSKI, CARY RAGAN · 2018 to 2022
$923kBlimp-1-mediated Th2 cell development in the lung impacting allergic airway inflammationR21AI135027 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2018 to 2019
$409kHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI152104NCI NIH HHS T32 CA082084NIAID NIH HHS R01 AI153104NIAID NIH HHS R21 AI135027NIDDK NIH HHS K08 DK118211NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK118726NIDDK NIH HHS R01 DK125049
Abstract
The multiligand receptors megalin (
Indexed as
CRISPR-Cas SystemsGene Knockout TechniquesTranscription, GeneticAdaptor Proteins, Signal TransducingAgenesis of Corpus CallosumAnimalsApoptosis Regulatory ProteinsCells, CulturedCRISPR-Associated Protein 9Databases, GeneticGene Regulatory NetworksHearing Loss, SensorineuralHernias, Diaphragmatic, CongenitalHumansKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCRISPR-Associated Protein 9DAB2 protein, humanDab2 protein, mouseintrinsic factor-cobalamin receptorLow Density Lipoprotein Receptor-Related Protein-2LRP2 protein, humanLrp2 protein, mouseReceptors, Cell SurfaceDonnai-Barrow syndromeendocytosisrenal proximal tubule cellsodium-glucose cotransporter isoform 2transcriptional profiling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.