Evidence map›Paper›PMID 34746967›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

The effect of systemic application of propolis on tongue damage and oral mucositis in rats exposed to radiation.

Gulhan Guler Avci, Ibrahim Erdim, Zeliha Cansel Ozmen, Fikret Gevrek, Sefa Colak, Mustafa Sami Demirsoy, Halis Bozkurt

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Clinical Evidence on the Use of Propolis for Oral Mucositis.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gulhan Guler AvciFaculty of Medicine, Department of Radiation Oncology, Gaziosmanpaşa University, Tokat, Turkey. drgulhanguler@hotmail.com.ORCID http://orcid.org/0000-0001-6802-2984
Ibrahim ErdimFaculty of Medicine, Department of Otolaryngology, Gaziosmanpaşa University, Tokat, Turkey.
Zeliha Cansel OzmenFaculty of Medicine, Department of Medical Biochemistry, Gaziosmanpaşa University, Tokat, Turkey.
Fikret GevrekFaculty of Medicine, Department of Histology and Embryology, Gaziosmanpaşa University, Tokat, Turkey.
Sefa ColakMedical Dentist, Tokat Private Dental Practice, Tokat, Turkey.
Mustafa Sami DemirsoyFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Sakarya University, Sakarya, Turkey.
Halis BozkurtFaculty of Medicine, Department of Radiation Oncology, Gaziosmanpaşa University, Tokat, Turkey.
Tokat Gaziosmanpaşa Üniversitesi · TRSakarya University · TR

Funding

Gaziosmanpasa Üniversitesi scientific research project no 2020-113
6 · The paper itself

Abstract

purposeIn this experimental study, the effect of dose-dense systemic application of propolis on oral mucosity, histological changes in papilla, and inflammatory and hypoxic markers in rats exposed to radiation was investigated.

methodsSeven rats were in the control and 30 rats in the experimental group. Three experimental groups were formed. In Group 1 RT (15 Gy) was delivered only to the head and neck region. In Group 2, RT (15 Gy) and systemic administration of 100 mg/kg/ml propolis, in Group 3, RT (15 Gy) and systemic administration of 200 mg/kg/ml propolis were applied. Oral mucositis index (OMI) was scored in control and experimental groups. Proinflammatory markers [interleukin-6 (IL-6), myeloperoxidase (MPO), tumor-necrosis factor-α (TNF-α)] hypoxia markers [glucose transporter-1 (GLUT-1), hypoxia-inducible factor 1α (HIF-1α)] were studied histomorphologically.

resultsThe significantly highest OMI score was observed in the G1. OMI score was statistically significantly decreased in experimental groups receiving systemic propolis, especially in G3. Proinflammatory markers increased significantly only in the experimental RT group, G1. Serum levels of MPO and TNF-α significantly decreased in the dose-dense systemic propolis arm. The highest levels of hypoxia markers (HIF-1α and GLUT-1) were detected in the RT group, then in G2, G3, and control groups in order of decreasing frequency. However, the difference between the groups did not reach the level of statistical significance.

conclusionSystemic propolis can be reduced acute mucositis with its anti-inflammatory effect without developing resistance to RT (tumor protection). However, greater number of clinical studies should be designed to arrive at definitive conclusions.

Indexed as

MucositisPropolisStomatitisAnimalsHypoxia-Inducible Factor 1, alpha SubunitRatsTongueTumor Necrosis Factor-alphaHypoxia-Inducible Factor 1, alpha SubunitPropolisTumor Necrosis Factor-alphaAnti-inflammatoryHypoxiaOral mucositisPropolisRadiotherapyRat

Identifiers

PMID34746967
OpenAlexW3213602497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.