Evidence map›Paper›PMID 34746955›Full record

Trial reportEuropean heart journal2022

Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: the Generation 100 randomized trial.

Jon Magne Letnes, Ida Berglund, Kristin E Johnson, Håvard Dalen, Bjarne M Nes, Stian Lydersen, Hallgeir Viken, Erlend Hassel, Sigurd Steinshamn, Elisabeth Kleivhaug Vesterbekkmo and 15 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01666340 (Generation 100), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01666340 naactive not recruitingnot on this map

Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2012 to 2026Enrolled1,567ConditionsAgeingArmsExercise intervention
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. An Intelligent Cardiopulmonary Training System and Adherence to Training Intensity: A Feasibility Study.International journal of environmental research and public health · 2022
    Trial
  5. Article
  6. Article
  7. Article
  8. Exercise and Kidney Function in Care of Older Adults.Journal of the American Society of Nephrology : JASN · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Jon Magne LetnesDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-2877-9904
Ida BerglundDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0001-9462-548X
Kristin E JohnsonDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-5470-7138
Håvard DalenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0003-1192-3663
Bjarne M NesDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-9958-8179
Stian LydersenRegional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0001-6613-8596
Hallgeir VikenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Erlend HasselNorwegian Armed Forces Occupational Health Service, Post Box 800, Lillehammer 2617, Norway.ORCID 0000-0003-3282-8921
Sigurd SteinshamnDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-4867-8641
Elisabeth Kleivhaug VesterbekkmoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0001-5776-3533
Asbjørn StøylenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-2245-7066
Line S ReitloDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Nina ZiskoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Fredrik H BækkerudDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.ORCID 0000-0002-8409-8599
Atefe R TariDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Jan Erik IngebrigtsenDepartment of Sociology and Political Science, Faculty of Social and Educational Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Silvana B SandbakkDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Trude CarlsenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Sigmund A AnderssenDepartment of Sports Medicine, The Norwegian School of Sport Sciences, Sognsveien 220, Oslo 0863, Norway.
Maria A Fiatarone SinghSydney School of Health Sciences and Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Science, University of Queensland, Human Movement Studies Building, St Lucia QLD, Queensland 4067, Australia.ORCID 0000-0002-6990-3596
Jorunn L HelbostadDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Øivind RognmoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Ulrik WisløffDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.
Dorthe StensvoldDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, Trondheim 7491, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study was to compare the effects of 5 years of supervised exercise training (ExComb), and the differential effects of subgroups of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), with control on the cardiovascular risk profile in older adults. METHODS AND

resultsOlder adults aged 70-77 years from Trondheim, Norway (n = 1567, 50% women), able to safely perform exercise training were randomized to 5 years of two weekly sessions of HIIT [∼90% of peak heart rate (HR), n = 400] or MICT (∼70% of peak HR, n = 387), together forming ExComb (n = 787), or control (instructed to follow physical activity recommendations, n = 780). The main outcome was a continuous cardiovascular risk score (CCR), individual cardiovascular risk factors, and peak oxygen uptake (VO2peak). CCR was not significantly lower [-0.19, 99% confidence interval (CI) -0.46 to 0.07] and VO2peak was not significantly higher (0.39 mL/kg/min, 99% CI -0.22 to 1.00) for ExComb vs. control. HIIT showed higher VO2peak (0.76 mL/kg/min, 99% CI 0.02-1.51), but not lower CCR (-0.32, 99% CI -0.64 to 0.01) vs. control. MICT did not show significant differences compared to control or HIIT. Individual risk factors mostly did not show significant between-group differences, with some exceptions for HIIT being better than control. There was no significant effect modification by sex. The number of cardiovascular events was similar across groups. The healthy and fit study sample, and contamination and cross-over between intervention groups, challenged the possibility of detecting between-group differences.

conclusionsFive years of supervised exercise training in older adults had little effect on cardiovascular risk profile and did not reduce cardiovascular events. REGISTRATION: ClinicalTrials.gov: NCT01666340.

Indexed as

Cardiovascular DiseasesHigh-Intensity Interval TrainingAgedExerciseFemaleHeart Disease Risk FactorsHumansMaleOxygen ConsumptionRisk FactorsAgeingCardiorespiratory fitnessCardiovascular risk factorsExerciseHigh-intensity interval training

Identifiers

PMID34746955
PMCPMC9156390

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.