Evidence map›Paper›PMID 34746935›Full record

ArticleJournal of cancer biology2021

Implications of the USP10-HDAC6 axis in lung cancer - A path to precision medicine.

Xiaohong Mary Zhang, Navnath Gavande, Prahlad Parajuli, Gerold Bepler

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiaohong Mary ZhangDepartment of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R. Street, Detroit, Michigan, 48201, USA.
Navnath GavandeDepartment Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan, 48201, USA.
Prahlad ParajuliDepartment of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R. Street, Detroit, Michigan, 48201, USA.
Gerold BeplerDepartment of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R. Street, Detroit, Michigan, 48201, USA.
The Barbara Ann Karmanos Cancer Institute · USEugene Applebaum College of Pharmacy and Health Sciences · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
Targeting USP10 to regulate the DNA damage response in NSCLCR21CA256423 · NCI · WAYNE STATE UNIVERSITY · PI BEPLER, GEROLD, ZHANG, XIAOHONG MARY · 2021 to 2022
$392k
NCI NIH HHS P30 CA022453NCI NIH HHS R21 CA256423
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer death among both men and women in the United States. Because lung cancer is genetically heterogeneous, tailored therapy alone or in combination with chemotherapy would increase patient overall survival as compared with the one-size-fits-all chemotherapy.

Identifiers

PMID34746935
PMCPMC8570638
OpenAlexW3213110122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.