ArticleInternational journal of cardiology. Cardiovascular risk and prevention2021
The association between periodontitis and cardiovascular risks in asymptomatic healthy patients.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between atherosclerosis and tooth loss in adult patients: systematic review and meta-analysis.Evidence-based dentistry · 2026Pooled it
- The oral and lower airway microbiota and coronary heart disease in COPD patients and controls.PloS one · 2026Article
- Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study.Journal of periodontal research · 2025Article
- Article
- Association between periodontitis and cardiovascular risk in Spanish employed adults-The Workers' Oral Health study.Journal of periodontal research · 2025Article
- Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study.Frontiers in oral health · 2025Article
- Periodontal Inflammation and Dysbiosis Relate to Microbial Changes in the Gut.Microorganisms · 2024Article
- Advanced machine learning for estimating vascular occlusion percentage in patients with ischemic heart disease and periodontitis.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Changes in Dickkopf-1, but Not Sclerostin, in Gingival Crevicular Fluid Are Associated with Peroral Statin Treatment in Patients with Periodontitis.Medicina (Kaunas, Lithuania) · 2024Article
- Can oral health care be a gateway to improve cardiovascular disease? A scoping review.Frontiers in oral health · 2024Article
- Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients.Open medicine (Warsaw, Poland) · 2024Review
- Ultra-low radiation dose and contrast volume CT protocol and TAVI-CT score for TAVI planning and outcome.The British journal of radiology · 2023Article
- Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up.Journal of clinical medicine · 2022Article
- The Effect of Periodontal Treatment on the Reactive Hyperemia Index. A 1-Year Follow-Up Pilot Study.Frontiers in cardiovascular medicine · 2022Article
- Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis is a chronic multifactorial inflammatory disease of the supportive tissues of the teeth. Pathophysiological evidence suggests a possible common inflammatory background between periodontitis and cardiovascular diseases (CVD). Pathological and epidemiological associations between these two diseases have been presented, but are still debated. This study aimed to investigate the association between the inflammatory burden of periodontitis and the presence and extent of coronary calcification. Secondary aims were to study other cardiovascular parameters and cardiovascular risk predictors in relation to periodontitis and dental health.
methodsHealthy periodontitis or non-periodontitis patients 45-70 years of age were included in a prospective cross-sectional study. Full-mouth examinations were performed by a periodontist to determine their Periodontal Inflamed Surface Area (PISA) score and other dental parameters. To assess the cardiovascular conditions, Coronary Artery Calcium (CAC) scores, endothelial function assessments by the EndoPAT ™, and several physical and biochemical examinations were performed.
resultsSeventy-one patients were included. Elevated CAC scores and endothelial dysfunction were not significantly related to PISA or dental health. PISA was significantly related to the Framingham and Reynolds CVD risk predictors, but were no longer significant after correction for confounders. The same applied to the significant relations between tooth loss, dental plaque and bleeding scores and the CVD risk predictors.
conclusionsPeriodontitis is associated with increased CVD risk, but is not an independent risk factor. This link is still important to make to bridge the gap between dentistry and general medicine and to identify patients at risk for CVD in an earlier stage.
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