Evidence map›Paper›PMID 34746879›Full record

ArticleBrain, behavior, & immunity - health2021

Using quantitative MRI to study brain responses to immune challenge with interferon-α.

Maria Antonietta Nettis, Andrew J Lawrence, Tobias Wood, Nicole Mariani, Naghmeh Nikkheslat, Giulia Lombardo, Daniela Enache, Mattia Veronese, Federico E Turkheimer, Paola Dazzan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Antonietta NettisKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Andrew J LawrenceKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Tobias WoodKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Neuroimaging, London, UK.
Nicole MarianiKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Naghmeh NikkheslatKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Giulia LombardoKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Daniela EnacheKarolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Stockholm, Sweden.
Mattia VeroneseNational Institute for Health Research Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
Federico E TurkheimerKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Neuroimaging, London, UK.
Paola DazzanKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Carmine M ParianteKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Valeria MondelliKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.

Funding

MRF_ C0439MRF_ MRF-160-0005-ELP-MONDE
6 · The paper itself

Abstract

Inflammatory processes in the Central Nervous System (CNS) have been proposed to mediate the association between peripheral inflammation and the development of psychiatric disorders, but we currently lack sensitive measures of CNS inflammation for human studies

Indexed as

DepressionInterferon-αMRINeuroinflammationQuantitative relaxometry

Identifiers

PMID34746879
PMCPMC8554453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.