Evidence map›Paper›PMID 34746861›Full record

ArticleSTAR protocols2021

Mass production of human airway-like neutrophils via transmigration in an organotypic model of human airways.

Brian Dobosh, Vincent D Giacalone, Camilla Margaroli, Rabindra Tirouvanziam

Abstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brian DoboshDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Vincent D GiacaloneDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Camilla MargaroliDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Rabindra TirouvanziamDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Funding

Contribution of neutrophils to early airway disease in cystic fibrosis childrenR01HL126603 · NHLBI · EMORY UNIVERSITY · PI TIROUVANZIAM, RABINDRA MARIE-JEAN · 2015 to 2018
$1.7M
NHLBI NIH HHS R01 HL126603
6 · The paper itself

Abstract

Neutrophils are difficult to study, particularly in tissues, due to their short half-life and propensity for activation. We describe an organotypic airway model that uses patient airway fluid to enable the transmigration of blood neutrophils to acquire an airway-like phenotype in order to better understand their contribution to airway diseases. In particular, we showcase how conditioned neutrophils modulate their bacteria-killing abilities. For complete details on the use and execution of this protocol, please refer to Margaroli et al. (2021).

Indexed as

NeutrophilsRespiratory MucosaBacteriaCell Culture TechniquesCell MovementCells, CulturedCell TransdifferentiationHumansMicrobial ViabilityModels, BiologicalCell-based AssaysCell cultureCell isolationImmunology

Identifiers

PMID34746861
PMCPMC8551927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.