Evidence map›Paper›PMID 34746731›Full record

ArticleMetabolism open2021

Real world evidence: Patients with refractory pemphigus treated with Rituximab.

Vagiani Perifani, Maria Dalamaga, Konstantinos Theodoropoulos, Sofia Theotokoglou, Anna Syrmali, Panagiota Loumou, Evangelia Papadavid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vagiani Perifani2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Maria Dalamaga2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Konstantinos Theodoropoulos2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Sofia Theotokoglou2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Anna Syrmali2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Panagiota Loumou2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
Evangelia Papadavid2nd Department of Dermatology and Venereology, Unit of Autoimmune Skin Disorders, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 124 62, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPemphigus is a group of autoimmune blistering diseases, potentially life-threatening. Rituximab received FDA approval in June 2018 for the treatment of moderate to severe pemphigus vulgaris.

objectivesTo evaluate the efficacy and safety of rituximab in patients with pemphigus, resistant to previous therapies or unable to receive classic immunosuppressive treatment due to serious adverse events or comorbidities. MATERIALS AND

methodsTwenty-five patients (9 men, 16 women), mean age 49.4 ± 15.9 years (range 21-74 years), mean disease duration 4 ± 2.7 years (range 0.25-10 years) were included in the study: 19 patients with pemphigus vulgaris and 6 with pemphigus foliaceous. The efficacy of rituximab was evaluated according to the control of disease, retention of remission, disease severity, previous treatments and adverse reactions. During COVID-19 pandemic patients are monitored closely through tele-dermatology.

resultsTwenty-three out of 25 patients had great improvement, 2 out of 25 ceased therapy due to adverse events (arthralgias and dyspnea). Sixteen out of 23 received additional course after 8 months (range 5-60 months). More aged patients presented more frequently adverse events and underwent additional courses (p = 0.002). Rituximab was found superior to classic immunosuppressive treatment in terms of efficacy and safety, with larger periods of remission and lower doses of corticosteroids and immunosuppressants. No major adverse events were noticed.

conclusionsRituximab is a very effective treatment of pemphigus and, remarkably, superior to classic immunosuppressive treatment.

Indexed as

Autoimmune blistering diseaseBiologicEfficacyImmunosuppressionPemphigusRituximabSafety

Identifiers

PMID34746731
PMCPMC8551647
OpenAlexW3207446812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.