Evidence map›Paper›PMID 34746729›Full record

ReviewCJC open2021

Right Ventricular Outflow Tract Obstruction in Adults: A Systematic Review and Meta-analysis.

Yu Hao Zeng, Alexander Calderone, Nicolas Rousseau-Saine, Mahsa Elmi-Sarabi, Stéphanie Jarry, Étienne J Couture, Matthew P Aldred, Jean-Francois Dorval, Yoan Lamarche, Lachlan F Miles and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in CJC open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Endovascular Forceps Biopsy of Pulmonary Artery Intimal Sarcoma: A Safer Approach.American journal of respiratory and critical care medicine · 2025
    Article
  6. Review
  7. [MEP-40] Right Ventricular Myxoma: A Rare Case.Turk gogus kalp damar cerrahisi dergisi · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yu Hao ZengDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Alexander CalderoneDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Nicolas Rousseau-SaineDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Mahsa Elmi-SarabiDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Stéphanie JarryDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Étienne J CoutureDepartment of Anesthesiology and Department of Medicine, Division of Intensive Care Medicine, Quebec Heart & Lung Institute, Quebec, Quebec, Canada.
Matthew P AldredDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Jean-Francois DorvalDepartment of Cardiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Yoan LamarcheDepartment of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Lachlan F MilesDepartment of Critical Care, The University of Melbourne, Melbourne, Victoria, Australia and Department of Anaesthesia, Austin Health, Melbourne, Australia.
William Beaubien-SoulignyDepartment of Medicine, Nephrology Division, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
André Y DenaultDepartment of Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Montreal Heart Institute · CAUniversité de Montréal · CAAustin Health · AUCentre Hospitalier de l’Université de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular outflow tract obstruction (RVOTO) is a cause of hemodynamic instability that can occur in several situations, including cardiac surgery, lung transplantation, and thoracic surgery, and in critically ill patients. The timely diagnosis of RVOTO is important because it requires specific considerations, including the adverse effects of positive inotropes, and depending on the etiology, the requirement for urgent surgical intervention.

methodsThe objective of this systematic review and meta-analysis was to determine the prevalence of RVOTO in adult patients, and the distribution of all reported cases by etiology.

resultsOf 233 available reports, there were 229 case reports or series, and 4 retrospective cohort studies, with one study also reporting a prospective cohort. Of 291 reported cases of RVOTO, 61 (21%) were congenital, 56 (19%) were iatrogenic, and 174 (60%) were neither congenital nor iatrogenic (including intracardiac tumour). The mechanism of RVOTO was an intrinsic obstruction in 169 cases (58%), and an extrinsic obstruction in 122 cases (42%). A mechanical obstruction causing RVOTO was present in 262 cases (90%), and 29 cases of dynamic RVOTO (10%) were reported. In the 5 included cohorts, with a total of 1122 patients, the overall prevalence was estimated to be 4.0% (1%-9%).

conclusionsRVOTO, though rare, remains clinically important, and therefore, multicentre studies are warranted to better understand the prevalence, causes, and consequences of RVOTO.

Identifiers

PMID34746729
PMCPMC8551422
OpenAlexW3156836258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.