Evidence map›Paper›PMID 34746716›Full record

ArticleEClinicalMedicine2021

Examining health-related quality of life in pediatric cancer patients with febrile neutropenia: Factors predicting poor recovery in children and their parents.

Anna Crothers, Gabrielle M Haeusler, Monica A Slavin, Franz E Babl, Francoise Mechinaud, Robert Phillips, Heather Tapp, Bhavna Padhye, David Zeigler, Julia Clark and 5 more

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. A Review of the Role of Neuroimaging in Neurotoxicity Monitoring in Children with Acute Lymphoblastic Leukemia.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 3 countries.

Anna CrothersCentre for Health Economics Research and Evaluation, University of Technology Sydney, Australia.
Gabrielle M HaeuslerDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Monica A SlavinDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Franz E BablMurdoch Children's Research Institute, Parkville, Australia.
Francoise MechinaudUnité d'hématologie immunologie pédiatrique, Hopital Robert Debré, APHP Nord Université de Paris, France.
Robert PhillipsCentre for Reviews and Dissemination, University of York, York, UK.
Heather TappDepartment of Oncology, Women's and Children's Hospital, Adelaide, Australia.
Bhavna PadhyeCancer Centre for Children, Westmead Children's Hospital, Sydney, Australia.
David ZeiglerKid's Cancer Centre, Sydney Children's Hospital, Sydney, Australia.
Julia ClarkInfection Management Service, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.
Thomas WalwynDepartment of Oncology, Perth Children's Hospital, Perth, Australia.
Leanne SuperChildren's Cancer Centre, Monash Children's Hospital, Monash Health, Melbourne, Australia.
Frank AlvaroChildren's Cancer Department, John Hunter Children's Hospital, University of Newcastle, Newcastle, Australia.
Karin ThurskyDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Richard De Abreu LourencoCentre for Health Economics Research and Evaluation, University of Technology Sydney, Australia.
Royal Children's Hospital · AUThe University of Melbourne · AUUniversity of Technology Sydney · AUChildren’s Health Queensland Hospital and Health Service · AUChildren's Hospital at Westmead · AUJohn Hunter Children's Hospital · AULeeds General Infirmary · GBMonash Children’s Hospital · AUPrincess Margaret Hospital for Children · AUSydney Children's Hospital · AUUniversité Paris Cité · FRWomen's and Children's Hospital · AU

Funding

Medical Research Council G0800472
6 · The paper itself

Abstract

backgroundThe impact febrile neutropenia (FN) has on the health-related quality of life (HRQoL) of children with cancer and their families is poorly understood. We sought to characterize the course of child and parent HRQoL during and following FN episodes.

methodData on HRQoL were collected in the multisite Australian Predicting Infectious ComplicatioNs in Children with Cancer (PICNICC) study. Participants were enrolled between November 2016 to January 2018. The Child Health Utility (CHU9D) was used to assess HRQoL in children (

findingsFor children, three distinct groups were identified: persistently low HRQoL over the 30-day course of follow-up (chronic:

interpretationApproximately half the children and parents had chronically low HRQoL scores, which did not improve following resolution of the FN episode. The child's sex, cancer type, and presence of financial and relationship stress were predictive of chronic group membership for both parents and children. These families may benefit from increased financial and psychosocial support during anti-cancer treatment.

fundingNational Health and Medical Research Council Grant (APP1104527).

Indexed as

CancerChildFebrile neutropeniaFeverHealth-related quality of lifeParent, pediatric cancerPediatric oncology

Identifiers

PMID34746716
PMCPMC8548915
OpenAlexW3193468009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.