Evidence map›Paper›PMID 34746705›Full record

ArticleiScience2021

Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues.

Hye-Ran Moon, Soutick Saha, Andrew Mugler, Bumsoo Han

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Directed migration of cancer cells: a systems biophysics perspective.Frontiers in cell and developmental biology · 2026
    Review
  2. Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hye-Ran MoonSchool of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, USA.
Soutick SahaDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
Andrew MuglerDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
Bumsoo HanSchool of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, USA.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Reprogramming PDAC Stroma by Targeting Coagulation in the Tumor MicroenvironmentU01CA274304 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Melissa L. Fishel, Matthew J. Flick · 2022 to 2026
$4.6M
Targeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2M
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitorsR01CA254110 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI FISHEL, MELISSA L., HAN, BUMSOO · 2021 to 2025
$2.1M
Dynamic Circadian Regulation of the Blood-Brain Interface in a Human Brain-mimicking Microfluid ChipR61HL159948 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GILLETTE, MARTHA U, HAN, BUMSOO · 2021 to 2022
$1.7M
Dynamic Circadian Regulation of the Blood-Brain Interface in a Human Brain-mimicking Microfluid ChipR33HL159948 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GILLETTE, MARTHA U, HAN, BUMSOO · 2023 to 2025
$1.4M
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA254110NCI NIH HHS U01 CA274304NHLBI NIH HHS R33 HL159948NHLBI NIH HHS R61 HL159948NHLBI NIH HHS U01 HL143403
6 · The paper itself

Abstract

Chemotaxis is ubiquitous in many biological processes, but it still remains elusive how cells sense and decipher multiple chemical cues. In this study, we postulate a hypothesis that the chemotactic performance of cells under complex cues is regulated by the signal processing capacity of the cellular sensory machinery. The underlying rationale is that cells

Indexed as

Cell biologyMathematical biosciencesSystems biology

Identifiers

PMID34746705
PMCPMC8554535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.