Evidence map›Paper›PMID 34746693›Full record

ArticleiScience2021

SLO2.1/NALCN a sodium signaling complex that regulates uterine activity.

Juan J Ferreira, Chinwendu Amazu, Lis C Puga-Molina, Xiaofeng Ma, Sarah K England, Celia M Santi

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. The sodium leak channel NALCN in Drd2Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Extending and outlining the genotypic and phenotypic spectrum of novel mutations of NALCN gene in IHPRF1 syndrome: identifying recurrent urinary tract infection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Juan J FerreiraDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Chinwendu AmazuDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Lis C Puga-MolinaDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Xiaofeng MaDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Sarah K EnglandDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Celia M SantiDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

A NOVEL MOLECULAR MECHANISM FOR STIMULATING UTERINE CONTRACTILITY BY OXYTOCINR01HD088097 · NICHD · WASHINGTON UNIVERSITY · PI Sarah K. England, Celia M Santi · 2016 to 2026
$4.1M
Signaling Mechanisms in Myometrial Cells that Modulate Na+ Leak Channel Non-Selective (NALCN) during Pregnancy and LaborF30HD095591 · NICHD · WASHINGTON UNIVERSITY · PI AMAZU, CHINWENDU · 2018 to 2021
$156k
NICHD NIH HHS F30 HD095591NICHD NIH HHS R01 HD088097
6 · The paper itself

Abstract

Depolarization of the myometrial smooth muscle cell (MSMC) resting membrane potential is necessary for the uterus to transition from a quiescent state to a contractile state. The molecular mechanisms involved in this transition are not completely understood. Here, we report that a coupled system between the Na

Indexed as

Biological sciencesCell biologyCellular physiologyFunctional aspects of cell biology

Identifiers

PMID34746693
PMCPMC8551532
OpenAlexW3204335719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.