Evidence map›Paper›PMID 34746593›Full record

ArticleACS omega2021

Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

Jia Wen Kong, Zhiyong Lam, Kiat Hwa Chan, Rakesh Ganguly, Jia-Ying Joey Lee, Lit-Hsin Loo, Richard D Webster, Zhen Xuan Wong, Weng Kee Leong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to cellular impact.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jia Wen KongDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Zhiyong LamDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Kiat Hwa ChanYale-NUS College, 16 College Avenue West, Singapore 138527, Singapore.
Rakesh GangulyDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.ORCID https://orcid.org/0000-0002-9523-6918
Jia-Ying Joey LeeAgency for Science, Technology, and Research (ASTAR), Bioinformatics Institute (BII), Singapore 138671, Singapore.
Lit-Hsin LooAgency for Science, Technology, and Research (ASTAR), Bioinformatics Institute (BII), Singapore 138671, Singapore.ORCID https://orcid.org/0000-0001-6303-9840
Richard D WebsterDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.ORCID https://orcid.org/0000-0002-0896-1960
Zhen Xuan WongDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Weng Kee LeongDivision of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.ORCID https://orcid.org/0000-0003-3198-7111
Nanyang Technological University · SGAgency for Science, Technology and Research · SGYale-NUS College · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os

Identifiers

PMID34746593
PMCPMC8567370
OpenAlexW3209933481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.