Evidence map›Paper›PMID 34746452›Full record

ArticlePhysics and imaging in radiation oncology2021

Deep learning auto-segmentation and automated treatment planning for trismus risk reduction in head and neck cancer radiotherapy.

Maria Thor, Aditi Iyer, Jue Jiang, Aditya Apte, Harini Veeraraghavan, Natasha B Allgood, Jennifer A Kouri, Ying Zhou, Eve LoCastro, Sharif Elguindi and 6 more

Open access · goldAbstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Artificial Intelligence in Head and Neck Surgery.Otolaryngologic clinics of North America · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Maria ThorDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Aditi IyerDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Jue JiangDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Aditya ApteDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Harini VeeraraghavanDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Natasha B AllgoodDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Jennifer A KouriDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Ying ZhouDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Eve LoCastroDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Sharif ElguindiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Linda HongDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Margie HuntDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Laura CerviñoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Michalis AristophanousDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Masoud ZarepishehDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Joseph O DeasyDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

background and purposeReducing trismus in radiotherapy for head and neck cancer (HNC) is important. Automated deep learning (DL) segmentation and automated planning was used to introduce new and rarely segmented masticatory structures to study if trismus risk could be decreased. MATERIALS AND

methodsAuto-segmentation was based on purpose-built DL, and automated planning used our in-house system, ECHO. Treatment plans for ten HNC patients, treated with 2 Gy × 35 fractions, were optimized (ECHO

resultsSmall systematic differences were observed between the doses to the six auto-segmented OARs and their manual counterparts (median: ECHO

conclusionsAutomated treatment planning can efficiently incorporate new structures from DL auto-segmentation, which results in trismus risk sparing without deteriorating treatment plan quality. Auto-planning and deep learning auto-segmentation together provide a powerful platform to further improve treatment planning.

Indexed as

CancerChewingDeep learningHead neckMasseterMasticationMedial pterygoidRadiationTrismus

Identifiers

PMID34746452
PMCPMC8552336
OpenAlexW3187702971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.