ArticleJournal of clinical tuberculosis and other mycobacterial diseases2021
Predictors of extrapulmonary tuberculosis among diabetic patients at Debre Markos compressive specialized hospital, Ethiopia, 2021: A retrospective cohort study.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.
- Diabetes as a risk factor for tuberculosis disease.The Cochrane database of systematic reviews · 2024Pooled it
- Undernutrition as a risk factor for tuberculosis disease.The Cochrane database of systematic reviews · 2024Pooled it
- An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male.Clinical case reports · 2026Article
- Risk Factors for Disseminated Tuberculosis and Associated Survival in Adults Without Human Immunodeficiency Virus.Open forum infectious diseases · 2025Article
- Prevalence and Associated Factors of Diabetes Mellitus Type 2 Among Tuberculosis Patients in Muscat, Oman, 2017-2020.Oman medical journal · 2023Article
- Knowledge of symptoms and delays in diagnosis of extrapulmonary tuberculosis patients in North Shewa zone, Ethiopia.PloS one · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
backgroundExtrapulmonary tuberculosis is an emerging public health problem among diabetic patients. Diabetes, which causes immunosuppression, is increasingly being recognized as an independent risk factor for tuberculosis, and the two often coexist and impact each other. Therefore, this study aimed to investigate the incidence and predictors of extra pulmonary tuberculosis among diabetic patients at Debre Markos referral hospital, Northwest Ethiopia.
methodsThis institutionally-based retrospective cohort study was undertaken among 433 diabetic patients of Debre Markos compressive specialized hospital between January 2016 to December 2020. All eligible diabetic patients who full filled the inclusion criteria were included in the study. Data were entered using Epi-data Version 3.1 and analyzed using STATA Version 14. The survival time of diabetic patients was estimated using the Kaplan-Meier survival curve, and the survival time between different categorical variables was compared using the log rank test. Both bi-variable and multivariable Cox-proportional hazard regression models were fitted to identify independent predictors of tuberculosis among diabetic patients.
resultsAmong a cohort of 433 diabetic patients at Debre Markos compressive specialized hospital, 17(3.9%) developed extra pulmonary tuberculosis during the follow-up time. The total time allotted to follow up the study participants was 1101.5 person-years (PY). The overall extra pulmonary tuberculosis incidence rate was 1.5 per 100 PY with 95% CI. Using the multivariable Cox-regression analysis, age (AIR 4.8 (95% CI (1.2-20.7), 0.03), diabetic medication (AIR 1.4 (95% CI(1.24-16), 0.03), having past history of PTB before diabetic follow up initiation (AID 1.5(95% CI (3.2-6.9),0.01) and having history of alcohol (AIR (95%CI (4(1.2-13),0.02) were significantly increased the risk of extra pulmonary tuberculosis while BMI (18.5-25) AIR(95% CI (0.22 (0.06-0.76), 0.02) was associated with a rate reduction for the incidence of extra pulmonary tuberculosis.
conclusionsIn this study, we found a high rate of extra pulmonary tuberculosis among diabetic patients. Factors significantly linked with increased risk of extra pulmonary tuberculosis included: age, using insulin as hypoglycemic medication, having past history of PTB before diabetic follow up initiation and alcoholic history while BMI was associated with a rate reduction of EPTB. Early screening and treatment for extra pulmonary tuberculosis is highly recommended at diabetes mellitus follow up for patients with the above risk factors.
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