Evidence map›Paper›PMID 34746420›Full record

ArticleEuropean stroke journal2021

Age-specific cerebral haemodynamic effects of early blood pressure lowering after transient ischaemic attack and non-disabling stroke.

Sara Mazzucco, Linxin Li, Iain J McGurgan, Maria A Tuna, Nicoletta Brunelli, Lucy E Binney, Peter M Rothwell, Oxford Vascular Study Phenotyped cohort

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sara MazzuccoNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.ORCID https://orcid.org/0000-0002-1582-6724
Linxin LiNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.ORCID https://orcid.org/0000-0002-3636-8355
Iain J McGurganNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.
Maria A TunaNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.
Nicoletta BrunelliCampus Bio-Medico University of Rome, Rome, Italy.
Lucy E BinneyNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.
Peter M RothwellNuffield Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford.ORCID https://orcid.org/0000-0001-9739-9211
Oxford Vascular Study Phenotyped cohort
University of Oxford · GBUniversità Campus Bio-Medico · IT

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionThere is limited knowledge of the effects of blood pressure (BP) lowering on cerebral haemodynamics after transient ischaemic attack (TIA) and non-disabling stroke, particularly at older ages. We aimed to evaluate changes in transcranial Doppler (TCD) haemodynamic indices in patients undergoing early blood pressure lowering after TIA/non-disabling stroke, irrespective of age. PATIENTS AND

methodsAmong consecutive eligible patients attending a rapid-access clinic with suspected TIA/non-disabling stroke and no evidence of extra/intracranial stenosis, hypertensive ones underwent intensive BP-lowering guided by daily home telemetric blood pressure monitoring (HBPM). Clinic-based BP, HBPM, End-tidal CO

resultsIn 697 patients with repeated TCD measures, mean/SD baseline systolic-BP (145.0/21.3 mmHg) was reduced by an average of 11.3/19.9 mmHg (

conclusionThere was no evidence of worsening of TCD haemodynamic indices associated with BP-lowering soon after TIA/non-disabling stroke, irrespective of age and degree of BP reduction. In fact, EDV increase and RI decrease observed after treatment of hypertensive patients suggest a decrease in distal vascular resistance.

Indexed as

ageblood pressurenon-disabling stroketranscranial DopplerTransient ischaemic attack

Identifiers

PMID34746420
PMCPMC8564162
OpenAlexW3197275581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.