Evidence map›Paper›PMID 34746367›Full record

ArticleJournal of advanced pharmacy research2021

Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids.

Hoda Elkafas, Osama Badary, Engy Elmorsy, Rehab Kamel, Qiwei Yang, Ayman Al-Hendy

Open access · diamondAbstract read
In one paragraph

Article in Journal of advanced pharmacy research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Hoda ElkafasDepartment of Pharmacology and Toxicology, Egyptian Drug Authority (EDA) formally, (NODCAR), Cairo 35521, Egypt.
Osama BadaryDepartment of Clinical Pharmacy, Faculty of Pharmacy, British University in Egypt, Cairo 11837, Egypt.
Engy ElmorsyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Rehab KamelDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Qiwei YangDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL, 60637, USA.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL, 60637, USA.
Helwan University · EGUniversity of Chicago · USBritish University in Egypt · EGUniversity of Illinois Chicago · US

Funding

Training the Trainers: Building Institutional Data Science Capacity to Support Health Disparities ResearchU54MD007602 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI Kevin Sean Kimbro · 2018 to 2026
$47.6M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Investigating the effectiveness of COVID-19 testing choices, community engagement, and culturally-embedded mHealth literacy delivery in a medically-underserved, community-based sampleR01ES028615 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AL-HENDY, AYMAN, WALKER, CHERYL L. · 2017 to 2022
$5.0M
Hypovitaminosis D promotes MED12-associated genomic instability in uterine fibroidsR01HD094378 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2018 to 2022
$4.2M
Mechanisms of actions(s) of simvastatin in uterine leiomyomaR01HD094380 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BORAHAY, MOSTAFA A. · 2018 to 2022
$4.0M
Implications of MTHFR Polymorphisms in Women receiving a Combination of Green Tea Extract and Fertility Promoting Drugs on Serum Folate LevelsR01HD100367 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AL-HENDY, AYMAN, GONZALEZ, FRANK · 2019 to 2023
$1.7M
NICHD NIH HHS R01 HD094378NICHD NIH HHS R01 HD094380NICHD NIH HHS R01 HD100367NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES028615NIMHD NIH HHS U54 MD007602
6 · The paper itself

Abstract

Uterine fibroids (UFs) are the most prevalent gynecologic neoplasm, affecting 70-80% of women over their lifespan. Although UFs are benign they can become life-threatening and require invasive surgeries such as myomectomy and hysterectomy. Notwithstanding the significant negative influence UFs have on female reproductive health, very little is known about early events that initiate tumor development. Several risk factors for UFs have been identified including vitamin D deficiency, inflammation, DNA repair deficiency, and environmental exposures to endocrine-disrupting chemicals (EDCs). EDCs have come under scrutiny recently due to their role in UF development. Epidemiologic studies have found an association between increased risk for early UF diagnosis and

Indexed as

DNA damageEDCsInflammationUterine fibroidsVitamin D3

Identifiers

PMID34746367
PMCPMC8570385
OpenAlexW3159754006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.