Evidence map›Paper›PMID 34746300›Full record

ArticleBioMed research international2021

Disorder Genes Regulate the Progression of Ischemic Stroke through the NF-

Wei Wei, Wenqiang Xin, Yufeng Tang, Zhonglun Chen, Yue Heng, Mingjun Pu, Bufan Yang, Jiacai Zuo, Jingfeng Duan

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei WeiDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Wenqiang XinDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Yufeng TangDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Zhonglun ChenDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Yue HengDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Mingjun PuDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Bufan YangDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Jiacai ZuoDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.
Jingfeng DuanDepartment of Neurology, Mianyang Central Hospital, Mianyang 621000, China.ORCID https://orcid.org/0000-0001-7015-0328
Mianyang Central Hospital · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is an acute cerebrovascular disease, including ischemic and hemorrhagic stroke. Stroke is the second leading cause of death after ischemic heart disease, which accounts for 9% of the global death toll. To explore the molecular mechanisms of the effects of the dysregulated factors, in the GEO database, we obtained transcriptome data from 24 h/72 h of mice with ischemic stroke and 24 h/72 h of normal mice. We then performed differential gene analysis, coexpression analysis, enrichment analysis, and regulator prediction bioinformatics analysis to identify the potential genes. We made a comparison between the ischemic stroke 72 h and the ischemic stroke for 24 h, and 5103 differential genes were obtained (

Indexed as

AnimalsComputational BiologyDatabases, GeneticGene ExpressionGene Regulatory NetworksIschemic StrokeMiceMicroRNAsNF-kappa BRNA, UntranslatedSignal TransductionSp1 Transcription FactorStrokeTranscriptomeMicroRNAsNF-kappa BRNA, UntranslatedSP1 protein, humanSp1 Transcription Factor

Identifiers

PMID34746300
PMCPMC8570099
OpenAlexW3209409000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.