Evidence map›Paper›PMID 34746036›Full record

ArticleFrontiers in cellular and infection microbiology2021

Proline Isomerization as a Key Determinant for Hsp90-Toxin Interactions.

Alisha Kellner, Patrick Cherubin, James K Harper, Ken Teter

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. An endogenous human peptide derived from αNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  5. Article
  6. Article
  7. Domperidone InhibitsToxins · 2023
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alisha KellnerBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
Patrick CherubinBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
James K HarperDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
Ken TeterBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
University of Central Florida · USBrigham Young University · US

Funding

A Novel Mechanism for Toxin Export from the Endoplasmic Reticulum to the CytosolR01AI099493 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI TETER, KENNETH R · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI099493
6 · The paper itself

Abstract

The A chains of ADP-ribosylating toxins exploit Hsp90 for translocation into the host cytosol. Here, we hypothesize that

Indexed as

Bacterial ToxinsProlineCholera ToxinHSP90 Heat-Shock ProteinsIsomerismProtein TransportBacterial ToxinsCholera ToxinHSP90 Heat-Shock ProteinsProlineAB toxinschaperonecholera toxinHsp90peptidyl prolyl cis-trans isomerasetoxin translocation

Identifiers

PMID34746036
PMCPMC8569296
OpenAlexW3212177232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.