Evidence map›Paper›PMID 34746026›Full record

ArticleFrontiers in cellular and infection microbiology2021

The ERK-p38MAPK-STAT3 Signalling Axis Regulates iNOS Expression and

Sheryl Erica Fernandes, Deepak Kumar Saini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Asiatic Acid AttenuatesInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sheryl Erica FernandesDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.
Deepak Kumar SainiDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.
Indian Institute of Science Bangalore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cellular changes occurring due to senescence like proliferation arrest, increase in free radical levels, and secretion of pro-inflammatory cytokines have been well studied, but its associated alteration in intracellular signalling networks has been scarcely explored. In this study, we examine the roles of three major kinases

Indexed as

MAP Kinase Signaling SystemSalmonella InfectionsCellular SenescenceHumansNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesSTAT3 Transcription FactorNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesSTAT3 protein, humanSTAT3 Transcription FactorERKiNOSp38 MAPKSalmonella typhimuriumsenescencesignallingSTAT3

Identifiers

PMID34746026
PMCPMC8569389
OpenAlexW3209102814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.