SynthesisFrontiers in oncology2021
Preoperative Serum Prealbumin Level and Adverse Prognosis in Patients With Hepatocellular Carcinoma After Hepatectomy: A Meta-Analysis.
Synthesis in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The clinical utility of serum prealbumin levels as a prognostic marker in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: a meta-analysis of 2,996 patients.Frontiers in oncology · 2026Pooled it
- Preoperative Bioelectrical Impedance Analysis Identifies Altered Body Composition, Which Is Associated with Severe Postoperative Complications in Major Hepatopancreaticobiliary Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Risk factors for catheter-related complications after ultrasound-guided percutaneous transhepatic biliary drainage in malignant obstructive jaundice.BMC surgery · 2026Article
- Beyond Single Biomarkers: A Multidimensional Risk Score for Improved Post-Transplant Prognosis Prediction in Hepatocellular Carcinoma.Journal of inflammation research · 2026Article
- Subset of Child-Pugh Score 7 Shows Comparable Survival Outcomes to Child-Pugh Score 6 in Patients with Hepatocellular Carcinoma Treated with Atezolizumab and Bevacizumab.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Reference intervals for serum albumin, total protein, and prealbumin in healthy children in Nanning, China.Biomarkers in medicine · 2025Article
- Plasma proteomic analysis reveals altered protein abundances in HIV/HBV co-infection individuals with HCC and with liver cirrhosis.Scientific reports · 2025Article
- Article
- Inflammatory and nutritional markers in patients with resectable pancreatic cancer.Korean journal of clinical oncology · 2023Article
- Revisiting PINI Scoring in Light of Recent Biological Advances.Nutrients · 2023Review
- Plasma transthyretin is a nutritional biomarker in human morbidities.Frontiers of medicine · 2022Review
- Pharmacist-led standardization of total parenteral nutrition improves postoperative nutritional status in colorectal cancer patients.Annals of translational medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrealbumin is a sensitive indicator of liver function and nutritional status.
objectivesThis meta-analysis aimed to examine the association of the serum prealbumin level with the prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy.
methodsWe comprehensively searched the PubMed, Embase, Wanfang, China Academic Journals (CNKI), and SinoMed databases up to September 1, 2021. Eligible studies should report the association of the serum prealbumin level with prognosis and provide the multivariable-adjusted risk estimates of the outcomes of interest in HCC patients undergoing hepatectomy.
resultsA total of 11 studies with 7,442 HCC patients were identified and analyzed. Meta-analysis of a fixed effects model showed that a low serum prealbumin level was associated with poor overall survival [hazard ratio (HR) = 1.54, 95% confidence interval (CI) = 1.42-1.68], recurrence-free survival (HR = 1.34, 95% CI = 1.17-1.52), and a higher risk of postoperative hepatic insufficiency (HR = 2.21; 95% CI = 1.36-3.60) in HCC patients. Sensitivity and subgroup analyses confirmed the robustness of low serum prealbumin in predicting poor overall survival.
conclusionsThis meta-analysis indicated that a low preoperative serum prealbumin level was significantly associated with adverse prognosis in HCC patients undergoing hepatectomy.
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