ArticleBiomedical optics express2021
Time-domain NIRS system based on supercontinuum light source and multi-wavelength detection: validation for tissue oxygenation studies.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Inline dissolved-gas-derived oxygen saturation reference for dynamic blood phantoms at adult-head optical properties.Biomedical optics express · 2026Article
- Spectrally-resolved errors in absorption and reduced scattering due toBiomedical optics express · 2025Article
- Towards accurate penetration depth estimation in near-infrared spectroscopy: a quantitative analysis of source-detector distance dependence in porcine kidney models.Biomedical optics express · 2025Article
- Approaches for modelling autocorrelation function and data processing in time-domain diffuse correlation spectroscopy.Biomedical optics express · 2025Article
- Noninvasive monitoring of fetal tissue oxygenation level using time-domain NIRS.Journal of biomedical optics · 2025Article
- Minimum spectral resolution for continuous-wave hyperspectral near-infrared tissue spectroscopy.Journal of biomedical optics · 2025Article
- Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping.Journal of biomedical optics · 2025Article
- Brain Abnormalities During Self-Referential Task in Subthreshold Depression: A Near-Infrared Spectroscopy Study.Cureus · 2024Article
- Validation of multispectral imaging-based tissue oxygen saturation detecting system for wound healing recognition on open wounds.Journal of biomedical optics · 2024Article
- Leveraging 3D convolutional neural network and 3D visible-near-infrared multimodal imaging for enhanced contactless oximetry.Journal of biomedical optics · 2024Article
- Tutorial on methods for estimation of optical absorption and scattering properties of tissue.Journal of biomedical optics · 2024Article
- A Novel Approach to Evaluating Crosstalk for Near-Infrared Spectrometers.Sensors (Basel, Switzerland) · 2024Article
- HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation.Journal of biomedical optics · 2024Article
- Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs.Biomedical optics express · 2023Article
- Continuous-wave parallel interferometric near-infrared spectroscopy (CWBiomedical optics express · 2022Article
- Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.Journal of biomedical optics · 2022Article
- Machine learning enabled multiple illumination quantitative optoacoustic oximetry imaging in humans.Biomedical optics express · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
We present and validate a multi-wavelength time-domain near-infrared spectroscopy (TD-NIRS) system that avoids switching wavelengths and instead exploits the full capability of a supercontinuum light source by emitting and acquiring signals for the whole chosen range of wavelengths. The system was designed for muscle and brain oxygenation monitoring in a clinical environment. A pulsed supercontinuum laser emits broadband light and each of two detection modules acquires the distributions of times of flight of photons (DTOFs) for 16 spectral channels (used width 12.5 nm / channel), providing a total of 32 DTOFs at up to 3 Hz. Two emitting fibers and two detection fiber bundles allow simultaneous measurements at two positions on the tissue or at two source-detector separations. Three established protocols (BIP, MEDPHOT, and nEUROPt) were used to quantitatively assess the system's performance, including linearity, coupling, accuracy, and depth sensitivity. Measurements were performed on 32 homogeneous phantoms and two inhomogeneous phantoms (solid and liquid). Furthermore, measurements on two blood-lipid phantoms with a varied amount of blood and Intralipid provide the strongest validation for accurate tissue oximetry. The retrieved hemoglobin concentrations and oxygen saturation match well with the reference values that were obtained using a commercially available NIRS system (OxiplexTS) and a blood gas analyzer (ABL90 FLEX), except a discrepancy occurs for the lowest amount of Intralipid.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.