ArticleBiomedical optics express2021
Dual-model wearable photoacoustic microscopy and electroencephalograph: study of neurovascular coupling in anesthetized and freely moving rats.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- Advances in Portable Optical Microscopy Using Cloud Technologies and Artificial Intelligence for Medical Applications.Sensors (Basel, Switzerland) · 2024Review
- Photoacoustic imaging of squirrel monkey cortical responses induced by peripheral mechanical stimulation.Journal of biophotonics · 2024Article
- Photoacoustic imaging plus X: a review.Journal of biomedical optics · 2024Review
- Review of low-cost light sources and miniaturized designs in photoacoustic microscopy.Journal of biomedical optics · 2024Review
- A Miniature Multi-Functional Photoacoustic Probe.Micromachines · 2023Article
- Looking deep inside tissue with photoacoustic molecular probes: a review.Journal of biomedical optics · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observing microscale neurovascular dynamics under different physiological conditions is of great importance to understanding brain functions and disorders. Here, we report a dual-model wearable device and an auxiliary data processing algorithm to derive neurovascular dynamics. The device integrates high-resolution photoacoustic microscopy and electroencephalography (EEG), which allows observing capillary-level hemodynamics and neural activities in anesthesia and freely moving rats. By using the developed algorithm, multiple photoacoustic/EEG parameters extracted and correlated enables investigation of the interplay between neural and vascular activities. We employed this platform to study the neurovascular coupling during different types of seizures in rats under various physiological conditions. We observed cerebral vascular vasodilation/constriction corresponding well to the seizure on/off in rats under regular anesthesia conditions, showing a strong neurovascular coupling coefficient. In rats under weak anesthesia and freely moving conditions, more intense cerebral hemodynamics and neural activities occurred with a weaker neurovascular coupling coefficient. The comprehensively quantitative analyses suggest that anesthesia has a dominant impact on the seizure onset and affect the neurovascular coupling correlation in the current drug-induced localized seizure model. Our study reveals that the designed platform has the potential to support studies on brain functions and disorders in diseased rodent models in various physiological states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.