ArticleBiomedical optics express2021
Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
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- Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals.Biomedical optics express · 2025Article
- Quantitative evaluation of the site-dependent cell viability in three-dimensional hepatocyte spheroids based on dynamic optical coherence tomography.Journal of biomedical optics · 2025Article
- Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation.Biomedical optics express · 2024Article
- Line-field dynamic optical coherence tomography platform for volumetric assessment of biological tissues.Biomedical optics express · 2024Article
- Cellular structural and functional imaging of donor and pathological corneas with label-free dual-mode full-field optical coherence tomography.Biomedical optics express · 2024Article
- Neural-network based high-speed volumetric dynamic optical coherence tomography.Biomedical optics express · 2024Article
- Dynamic contrast optical coherence tomography (DyC-OCT) for label-free live cell imaging.Communications biology · 2024Review
- Stem cell-based approaches for developmental neurotoxicity testing.Frontiers in toxicology · 2024Review
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- Dynamic optical coherence tomography for cell analysis [Invited].Biomedical optics express · 2023Review
- Label-free intratissue activity imaging of alveolar organoids with dynamic optical coherence tomography.Biomedical optics express · 2023Article
- Label-free, non-invasive, and repeatable cell viability bioassay using dynamic full-field optical coherence microscopy and supervised machine learning.Biomedical optics express · 2022Article
- Methods and applications of full-field optical coherence tomography: a review.Journal of biomedical optics · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamic full-field optical coherence microscopy (DFFOCM) was used to characterize the intracellular dynamic activities and cytoskeleton of HeLa cells in different viability states. HeLa cell samples were continuously monitored for 24 hours and compared with histological examination to confirm the cell viability states. The averaged mean frequency and magnitude observed in healthy cells were 4.79±0.5 Hz and 2.44±1.06, respectively. In dead cells, the averaged mean frequency was shifted to 8.57±0.71 Hz, whereas the magnitude was significantly decreased to 0.53±0.25. This cell dynamic activity analysis using DFFOCM is expected to replace conventional time-consuming and biopsies-required histological or biochemical methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.