Evidence map›Paper›PMID 34745744›Full record

ArticleBiomedical optics express2021

Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography.

Pablo Eugui, Conrad W Merkle, Johanna Gesperger, Antonia Lichtenegger, Bernhard Baumann

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pablo EuguiCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.ORCID https://orcid.org/0000-0002-3007-2385
Conrad W MerkleCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.ORCID https://orcid.org/0000-0002-2465-4100
Johanna GespergerCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Antonia LichteneggerCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.ORCID https://orcid.org/0000-0002-6422-9547
Bernhard BaumannCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.ORCID https://orcid.org/0000-0001-6419-1932
Medical University of Vienna · AT

Funding

Austrian Science Fund FWF J 4460
6 · The paper itself

Abstract

Cataracts are the leading cause of blindness worldwide. Here we propose optical coherence tomography (OCT) as a quantitative method for investigating cataracts. OCT provides volumetric and non-invasive access to the lens and makes it possible to rapidly observe the formation of opacifications in animal models such as mice. We compared the performance of two different wavelengths - 1060 nm and 1310 nm - for OCT imaging in cataract research. In addition, we present multi-contrast OCT capable of mapping depth-resolved scattering and average anterior cortical attenuation properties of the crystalline lens and quantitatively characterize induced cataract development in the mouse eye. Lastly, we also propose a novel method based on the retinal OCT projection image for quantifying and mapping opacifications in the lens, which showed a good correlation with scattering and attenuation characteristics simultaneously analyzed during the process of cataract formation in the lens.

Identifiers

PMID34745744
PMCPMC8547986
OpenAlexW3201506116

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.