Evidence map›Paper›PMID 34745735›Full record

ArticleBiomedical optics express2021

Femtosecond diode-based time lens laser for multiphoton microscopy.

Y Lange Simmons, Kenneth J Underwood, Omkar D Supekar, Brendan M Heffernan, Tarah A Welton, Emily A Gibson, Juliet T Gopinath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Y Lange SimmonsDepartment of Physics, University of Colorado, Boulder, CO 80309, USA.ORCID https://orcid.org/0000-0002-2392-1887
Kenneth J UnderwoodDepartment of Physics, University of Colorado, Boulder, CO 80309, USA.
Omkar D SupekarDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA.ORCID https://orcid.org/0000-0003-1777-8508
Brendan M HeffernanDepartment of Physics, University of Colorado, Boulder, CO 80309, USA.
Tarah A WeltonDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Emily A GibsonDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Juliet T GopinathDepartment of Physics, University of Colorado, Boulder, CO 80309, USA.ORCID https://orcid.org/0000-0003-2387-5371

Funding

Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out SpecificityR01NS118188 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CALDWELL, JOHN H, GIBSON, EMILY · 2020 to 2024
$3.3M
Development of a Bidirectional Optogenetic Minimally Invasive Peripheral Nerve Interface with Single Axon Read-in & Read-out SpecificityOT2OD023852 · OD · UNIVERSITY OF COLORADO DENVER · PI CALDWELL, JOHN H, GIBSON, EMILY · 2016 to 2018
$2.1M
NIH HHS OT2 OD023852NINDS NIH HHS R01 NS118188
6 · The paper itself

Abstract

We demonstrate a near-infrared, femtosecond, diode laser-based source with kW peak power for two-photon microscopy. At a wavelength of 976 nm, the system produces sub-ps pulses operating at a repetition rate of 10 MHz with kilowatt class peak powers suitable for deep tissue two-photon microscopy. The system, integrated with a laser-scanning microscope, images to a depth of 900 µm in a fixed sample of PLP-eGFP labeled mouse brain tissue. This represents a significant development that will lead to more efficient, compact, and accessible laser sources for biomedical imaging.

Identifiers

PMID34745735
PMCPMC8548023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.