Evidence map›Paper›PMID 34745712›Full record

ArticleACS catalysis2021

Implications for an imidazol-2-yl carbene intermediate in the rhodanase-catalyzed C-S bond formation reaction of anaerobic ergothioneine biosynthesis.

Ronghai Cheng, Rui Lai, Chao Peng, Juan Lopez, Zhihong Li, Nathchar Naowarojna, Kelin Li, Christina Wong, Norman Lee, Stephen A Whelan and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. How to Stabilize Carbenes in Enzyme Active Sites without Metal Ions.Journal of the American Chemical Society · 2022
    Article
  11. Article
  12. Review
  13. OvoAChemical science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Ronghai Cheng *Department of Chemistry, Boston University, Boston, MA 02215, USA.
Rui Lai *Department of Chemistry, Boston University, Boston, MA 02215, USA.
Chao Peng *National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
Juan LopezDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Zhihong LiNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
Nathchar NaowarojnaDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Kelin LiDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Christina WongDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Norman LeeDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Stephen A WhelanDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Lu QiaoDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Mark W GrinstaffDepartment of Chemistry, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. 0000-0002-5453-3668.
Jiangyun WangInstitute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
Qiang CuiDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Pinghua LiuDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Boston University · USShanghai Advanced Research Institute · CNChinese Academy of Sciences · CN

Funding

Development and application of QM/MM methods for metalloenzymesR01GM106443 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CUI, QIANG · 2013 to 2020
$2.3M
NIGMS NIH HHS R01 GM106443
6 · The paper itself

Abstract

In the anaerobic ergothioneine biosynthetic pathway, a rhodanese domain containing enzyme (EanB) activates tne hercynine's sp

Indexed as

anaerobic biosynthesiscarbene intermediateergothioneineQM/MM calculationselenonineunnatural amino acid (uAA)

Identifiers

PMID34745712
PMCPMC8570591
OpenAlexW3134836683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.