ArticleOrganic chemistry frontiers : an international journal of organic chemistry2021
Decarbonylative Sulfide Synthesis from Carboxylic Acids and Thioesters via Cross-Over C-S Activation and Acyl Capture.
Article in Organic chemistry frontiers : an international journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Humic acid as a natural catalyst for C-S bond construction: decarbonylative and decarboxylative thioether synthesis.RSC advances · 2025Article
- Access to thioethers from thiols and alcohols via homogeneous and heterogeneous catalysis.Scientific reports · 2023Article
- Forging C-S Bonds Through Decarbonylation: New Perspectives for the Synthesis of Privileged Aryl Sulfides.ChemCatChem · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A method for the synthesis of sulfides from carboxylic acids via thioester C-S activation and acyl capture has been accomplished, wherein thioesters serve as dual electrophilic activators to carboxylic acids as well as S-nucleophiles through the merger of decarbonylative palladium catalysis and sulfur coupling. This new concept engages readily available carboxylic acids as coupling partners to directly intercept sulfur reagents via redox-neutral thioester-enabled cross-over thioetherification. The scope of this platform is demonstrated in the highly selective decarbonylative thioetherification of a variety of carboxylic acids and thioesters, including late-stage derivatization of pharmaceuticals and natural products. This method operates under mild, external base-free, operationally-practical conditions, providing a powerful new framework to unlock aryl electrophiles from carboxylic acids and bolster the reactivity by employing common building blocks in organic synthesis.
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