Evidence map›Paper›PMID 34745518›Full record

ArticleChemical science2021

Coiled coils 9-to-5: rational

William M Dawson, Freddie J O Martin, Guto G Rhys, Kathryn L Shelley, R Leo Brady, Derek N Woolfson

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Designability of α-Helical Protein Filaments.Sub-cellular biochemistry · 2026
    Review
  2. Review
  3. Chemical science · 2025
    Article
  4. Article
  5. Article
  6. Confinement and Catalysis withinJournal of the American Chemical Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William M DawsonSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK w.dawson@bristol.ac.uk d.n.woolfson@bristol.ac.uk.ORCID https://orcid.org/0000-0003-2710-6879
Freddie J O MartinSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK w.dawson@bristol.ac.uk d.n.woolfson@bristol.ac.uk.
Guto G RhysSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK w.dawson@bristol.ac.uk d.n.woolfson@bristol.ac.uk.ORCID https://orcid.org/0000-0002-0247-9495
Kathryn L ShelleySchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK w.dawson@bristol.ac.uk d.n.woolfson@bristol.ac.uk.ORCID https://orcid.org/0000-0003-2206-7778
R Leo BradySchool of Biochemistry, University of Bristol Biomedical Sciences Building, University Walk Bristol BS8 1TD UK.ORCID https://orcid.org/0000-0002-3575-5513
Derek N WoolfsonSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK w.dawson@bristol.ac.uk d.n.woolfson@bristol.ac.uk.ORCID https://orcid.org/0000-0002-0394-3202

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1
6 · The paper itself

Abstract

The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discriminate between states are weak. Nonetheless, for α-helical coiled-coil assemblies considerable progress has been made in rational

Identifiers

PMID34745518
PMCPMC8503928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.