ArticleJournal of healthcare engineering2021
Integrating Optimized Multiscale Entropy Model with Machine Learning for the Localization of Epileptogenic Hemisphere in Temporal Lobe Epilepsy Using Resting-State fMRI.
Article in Journal of healthcare engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- A Multimodal Auxiliary Classification System for Osteosarcoma Histopathological Images Based on Deep Active Learning.Healthcare (Basel, Switzerland) · 2022Article
- Research on the MEG of Depression Patients Based on Multivariate Transfer Entropy.Computational intelligence and neuroscience · 2022Article
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8 authors.
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Abstract
The bottleneck associated with the validation of the parameters of the entropy model has limited the application of this model to modern functional imaging technologies such as the resting-state functional magnetic resonance imaging (rfMRI). In this study, an optimization algorithm that could choose the parameters of the multiscale entropy (MSE) model was developed, while the optimized effectiveness for localizing the epileptogenic hemisphere was validated through the classification rate with a supervised machine learning method. The rfMRI data of 20 mesial temporal lobe epilepsy patients with positive indicators (the indicators of epileptogenic hemisphere in clinic) in the hippocampal formation on either left or right hemisphere (equally divided into two groups) on the structural MRI were collected and preprocessed. Then, three parameters in the MSE model were statistically optimized by both receiver operating characteristic (ROC) curve and the area under the ROC curve value in the sensitivity analysis, and the intergroup significance of optimized entropy values was utilized to confirm the biomarked brain areas sensitive to the epileptogenic hemisphere. Finally, the optimized entropy values of these biomarked brain areas were regarded as the feature vectors input for a support vector machine to classify the epileptogenic hemisphere, and the classification effectiveness was cross-validated. Nine biomarked brain areas were confirmed by the optimized entropy values, including medial superior frontal gyrus and superior parietal gyrus (
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