Evidence map›Paper›PMID 34745444›Full record

ArticleJournal of oral microbiology2021

Pilot study on selective antimicrobial effect of a halitosis mouthrinse: monospecies and saliva-derived microbiome in an in vitro model system.

Márcia Botelho Dinis, Melissa Agnello, Xuesong He, Wenyuan Shi, Nini Chaichanasakul Tran

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Determination of low concentrations of glucose through colorimetric analysis using CoFeAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Márcia Botelho DinisSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-8734-4276
Melissa AgnelloM2Biome LLC, San Francisco, CA, USA.
Xuesong HeThe Forsyth Institute, Cambridge, MA, USA.ORCID https://orcid.org/0000-0002-3333-9188
Wenyuan ShiThe Forsyth Institute, Cambridge, MA, USA.
Nini Chaichanasakul TranSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-1716-4995
University of California, Los Angeles · USDiscoveryBioMed (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHalitosis refers to malodor emanating from the oral cavity. Several mouthrinses with halitosis-reduction exist on the market, but their effect on the oral microbiome is largely unknown. In this study, we used an efficient

methodsSingle halitosis-associated species and other common oral microorganism cultures were exposed to the test mouthrinse over time, and their viability was determined by culture-based selective plating. Next, the saliva-derived microbiome from healthy and halitosis-associated individuals was cultured in the presence of the test mouthrinse over time using the previously developed

resultsThe test mouthrinse displayed antimicrobial activity against known anaerobic bacterial species producing halitosis-related compounds such as

conclusionsThe test mouthrinse had promising anti-halitosis characteristics at the microbiome level, as demonstrated by the reduction in the relative abundance of halitosis-associated taxa while maintaining microbial diversity.

Indexed as

Antimicrobialhalitosismouthrinseoral microbiome

Identifiers

PMID34745444
PMCPMC8567964
OpenAlexW3208324072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.