Evidence map›Paper›PMID 34745371›Full record

ArticleCognitive computation2022

Deep Learning Approach for Early Detection of Alzheimer's Disease.

Hadeer A Helaly, Mahmoud Badawy, Amira Y Haikal

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In one paragraph

Article in Cognitive computation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hadeer A HelalyElectrical Engineering Department, Faculty of Engineering, Damietta University, Damietta, Egypt.ORCID 0000-0003-1529-9298
Mahmoud BadawyComputers and Control Systems Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, Egypt.
Amira Y HaikalComputers and Control Systems Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a chronic, irreversible brain disorder, no effective cure for it till now. However, available medicines can delay its progress. Therefore, the early detection of AD plays a crucial role in preventing and controlling its progression. The main objective is to design an end-to-end framework for early detection of Alzheimer's disease and medical image classification for various AD stages. A deep learning approach, specifically convolutional neural networks (CNN), is used in this work. Four stages of the AD spectrum are multi-classified. Furthermore, separate binary medical image classifications are implemented between each two-pair class of AD stages. Two methods are used to classify the medical images and detect AD. The first method uses simple CNN architectures that deal with 2D and 3D structural brain scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset based on 2D and 3D convolution. The second method applies the transfer learning principle to take advantage of the pre-trained models for medical image classifications, such as the VGG19 model. Due to the COVID-19 pandemic, it is difficult for people to go to hospitals periodically to avoid gatherings and infections. As a result, Alzheimer's checking web application is proposed using the final qualified proposed architectures. It helps doctors and patients to check AD remotely. It also determines the AD stage of the patient based on the AD spectrum and advises the patient according to its AD stage. Nine performance metrics are used in the evaluation and the comparison between the two methods. The experimental results prove that the CNN architectures for the first method have the following characteristics: suitable simple structures that reduce computational complexity, memory requirements, overfitting, and provide manageable time. Besides, they achieve very promising accuracies, 93.61% and 95.17% for 2D and 3D multi-class AD stage classifications. The VGG19 pre-trained model is fine-tuned and achieved an accuracy of 97% for multi-class AD stage classifications.

Indexed as

Alzheimer’s diseaseBrain MRIConvolutional neural network (CNN)Deep learningMedical image classification

Identifiers

PMID34745371
PMCPMC8563360

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.