Evidence map›Paper›PMID 34745130›Full record

ReviewFrontiers in immunology2021

Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.

Omayma Amin, Jenna Powers, Katherine M Bricker, Ann Chahroudi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The time is now to use the tools we have to end AIDS in children.Journal of the International AIDS Society · 2025
    Review
  6. Article
  7. RecombinantVaccines · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Pathogenesis of viral infections during pregnancy.Clinical microbiology reviews · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Omayma AminDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Jenna PowersDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Katherine M BrickerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · US

Funding

Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
The origin, predictors, and immune correlates of viral rebound in orally SHIV infected infant monkeysP01AI131276 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FOUDA AMOU OU, GENEVIEVE GINY · 2017 to 2021
$8.3M
Enhanced latency reversal and reservoir clearance in macaquesR37AI157862 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi · 2021 to 2026
$5.4M
Immune interventions in SIV-infected ART-suppressed infant macaquesR01AI133706 · NIAID · EMORY UNIVERSITY · PI CHAHROUDI, ANN M · 2017 to 2021
$4.1M
NIAID NIH HHS P01 AI131276NIAID NIH HHS R01 AI133706NIAID NIH HHS R37 AI157862NIAID NIH HHS UM1 AI164566
6 · The paper itself

Abstract

Despite the significant progress that has been made to eliminate vertical HIV infection, more than 150,000 children were infected with HIV in 2019, emphasizing the continued need for sustainable HIV treatment strategies and ideally a cure for children. Mother-to-child-transmission (MTCT) remains the most important route of pediatric HIV acquisition and, in absence of prevention measures, transmission rates range from 15% to 45%

Indexed as

HIV-1Infectious Disease Transmission, VerticalAnti-HIV AgentsBreast FeedingCD4 AntigensCoinfectionDelivery, ObstetricFemaleGenotypeHIV InfectionsHost-Pathogen InteractionsHumansInfantInfant, NewbornMaleMilk, HumanAnti-HIV AgentsCD4 AntigensReceptors, Virusantiretroviralbreast milkcureHIVMTCTpediatricreservoirshock and kill

Identifiers

PMID34745130
PMCPMC8566974
OpenAlexW3206343613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.