Evidence map›Paper›PMID 34745102›Full record

ArticleFrontiers in immunology2021

Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin.

Mareike Rentzsch, Robert Wawrzinek, Claudia Zelle-Rieser, Helen Strandt, Lydia Bellmann, Felix F Fuchsberger, Jessica Schulze, Jil Busmann, Juliane Rademacher, Stephan Sigl and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Synthetic Ligands of Myeloid C-Type Lectin Receptors.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
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  5. Article
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  8. Exploiting Unique Features of Microneedles to Modulate Immunity.Advanced materials (Deerfield Beach, Fla.) · 2023
    Review
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  12. Article
  13. Synthesis of glycopeptides and glycopeptide conjugates.Organic & biomolecular chemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Mareike RentzschDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Robert WawrzinekDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Claudia Zelle-RieserLangerhans Cell Research Lab, Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Helen StrandtLangerhans Cell Research Lab, Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Lydia BellmannLangerhans Cell Research Lab, Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Felix F FuchsbergerDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Jessica SchulzeDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Jil BusmannDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Juliane RademacherDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Stephan SiglDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Barbara Del FrariDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Patrizia StoitznerLangerhans Cell Research Lab, Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Christoph RademacherDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany.
Max Planck Institute of Colloids and Interfaces · DEInnsbruck Medical University · ATUniversität Innsbruck · ATUniversity of Vienna · AT

Funding

Austrian Science Fund FWF P 33855
6 · The paper itself

Abstract

Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation of the immune system, professional antigen presenting cells have proven to be key coordinators of such responses. Especially targeted approaches, actively directing antigens to specialized dendritic cells, promise to be more effective and accompanied by reduced payload due to less off-target effects. Although antibody and glycan-based targeting of receptors on dendritic cells have been employed, these are often expensive and time-consuming to manufacture or lack sufficient specificity. Thus, we applied a small-molecule ligand that specifically binds Langerin, a hallmark receptor on Langerhans cells, conjugated to a model protein antigen.

Indexed as

AnimalsAntigensAntigens, CDChlorocebus aethiopsCOS CellsGreen Fluorescent ProteinsHEK293 CellsHumansInjections, IntradermalLangerhans CellsLectins, C-TypeLigandsMannose-Binding LectinsMiniaturizationNanomedicineNeedlesAntigensAntigens, CDCD207 protein, humanGreen Fluorescent ProteinsLectins, C-TypeLigandsMannose-Binding LectinsVaccines, SubunitC-type lectinsLangerhans cellsLangerinmicroinjectionsubunit vaccinetargeted deliverytransdermalvaccine

Identifiers

PMID34745102
PMCPMC8566742
OpenAlexW3210031116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.