Evidence map›Paper›PMID 34745099›Full record

ArticleFrontiers in immunology2021

Identification and Evaluation of Recombinant Outer Membrane Proteins as Vaccine Candidates Against

Bao-Zhong Zhang, Danyu Hu, Ying Dou, Lifeng Xiong, Xiaolei Wang, Jingchu Hu, Shao-Zhen Xing, Wenjun Li, Jian-Piao Cai, Meiling Jin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Materials today. Bio · 2026
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  4. Review
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  8. Exploring current hypervirulentFrontiers in microbiology · 2025
    Review
  9. Article
  10. Animal models ofFrontiers in microbiology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Functional Annotation of Hypothetical Proteins From theBioinformatics and biology insights · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Bao-Zhong ZhangChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Danyu HuChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ying DouSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Lifeng XiongDepartment of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Xiaolei WangSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Jingchu HuChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Shao-Zhen XingSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Wenjun LiChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Jian-Piao CaiDepartment of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Meiling JinChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Mengya ZhangVaccine and Antibody Engineering, HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), Hangzhou, China.
Qiubin LinVaccine and Antibody Engineering, HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), Hangzhou, China.
Min LiSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong, SAR China.
Kwok-Yung YuenDepartment of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
Jian-Dong HuangChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
University of Hong Kong · HKChinese Academy of Sciences · CNShenzhen Institutes of Advanced Technology · CNChinese University of Hong Kong · CNHong Kong Baptist University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Vaccine DevelopmentAnimalsBacterial LoadBacterial Outer Membrane ProteinsBacterial VaccinesDisease Models, AnimalHL-60 CellsHumansImmunogenicity, VaccineKlebsiella InfectionsKlebsiella pneumoniaeMiceMice, Inbred BALB CPhagocytesPhagocytosisRecombinant ProteinsBacterial Outer Membrane ProteinsBacterial VaccinesRecombinant ProteinsVaccines, SyntheticKlebsiella pneumoniaeouter membrane proteinsproteomics and bioinformaticsserotype-independent vaccinesvaccine

Identifiers

PMID34745099
PMCPMC8564470
OpenAlexW3214354198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.