Evidence map›Paper›PMID 34745016›Full record

ReviewFrontiers in endocrinology2021

The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility.

Guannan Zhou, Yuanyuan Gu, Fangyue Zhou, Menglei Zhang, Ganrong Zhang, Ligang Wu, Keqin Hua, Jingxin Ding

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Guannan ZhouDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Yuanyuan GuDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Fangyue ZhouDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Menglei ZhangDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Ganrong ZhangDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Ligang WuState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Keqin HuaDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Jingxin DingDepartment of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Obstetrics and Gynecology Hospital of Fudan University · CNChinese Academy of Sciences · CNEast China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility is becoming much more common and affects more couples. The past years witnessed the rapid development of the diagnosis and treatment upon infertility, which give numerous coupled more opportunities become parents. Extracellular vesicles are known as nano-sized membrane vesicles to play a major role in intracellular communication. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and extracellular vesicles. However, the mechanism is still unclear. In this review, we reviewed the relationship between reproductive physiology and extracellular vesicles, and then collectively focused on the recent findings on the relationship between extracellular and infertility, and its consequent influence on the novel insight regarding the therapeutic strategies for infertility in the future clinical practice.

Indexed as

AnimalsDrug Delivery SystemsExtracellular VesiclesFemaleFertilization in VitroHumansInfertility, FemaleInfertility, MaleMaleextracellular vesiclesfemale infertilityIVFmale infertilitytherapeutics

Identifiers

PMID34745016
PMCPMC8569852
OpenAlexW3211285017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.