ArticleFrontiers in endocrinology2021
Circadian Rhythm Disruption Influenced Hepatic Lipid Metabolism, Gut Microbiota and Promoted Cholesterol Gallstone Formation in Mice.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The effects of time-restricted eating and Ramadan fasting on gut microbiota composition: a systematic review of human and animal studies.Nutrition reviews · 2024Pooled it
- Circadian regulation of hepatic detoxification: implications for drug-induced liver injury.Archives of toxicology · 2026Review
- Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis.Genes & diseases · 2026Article
- Circadian rhythms and microbiota: molecular crosstalk and its implications for health and disease.Biology direct · 2026Review
- Association of sleep disorder with increased risk of gallstone disease in adults in the United States: A cross-sectional study of the National Health and Nutrition Examination Survey (2017-2020).The Journal of international medical research · 2026Article
- Association between weekly sleep duration and gallstones in a US-based adult sample: A cross-sectional study.Medicine · 2025Article
- Transcriptome Analysis Reveals Circadian Rhythmic Regulation of Lipid Metabolism and Immune Function in Chicken Livers.Animals : an open access journal from MDPI · 2025Article
- Review
- The association between life's essential 8 and gallstones: A cross-sectional study.Scientific reports · 2025Article
- An association between average daily sleep duration and gallstones in US adults.Scientific reports · 2025Article
- NXT629 Ameliorates Cholesterol Gallstones in Mice Model by Improving Lipid Metabolism Disorder and Cholesterol Homeostasis Through Inhibiting the GPAM Pathway.Digestive diseases and sciences · 2025Article
- Relationship between mucin gene polymorphisms and different types of gallbladder stones.BMC medical genomics · 2025Article
- Associations of self-reported sleep disturbances, sleep onset, and duration with gallstone disease risk.Frontiers in nutrition · 2025Article
- Depressive symptoms mediate the association between sleep disorders and gallstone disease: a causal mediation analysis of NHANES 2017-2020.Frontiers in psychiatry · 2025Article
- Association between weekend catch-up sleep and gallstone disease in US adults: a cross-sectional study from NHANES 2017-2020.Frontiers in public health · 2025Article
- Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice.PPAR research · 2025Article
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Association between circadian syndrome and gallstones in US adult: a cross-sectional study of NHANES 2017-2020.BMC gastroenterology · 2024Article
- Association between sleep and gallstone disease in United States adults: A cross-sectional study.BMC public health · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatic lipid metabolism regulates biliary composition and influences the formation of cholesterol gallstones. The genes Methods: Adult male C57BL/6J mice were fed either a lithogenic diet (LD) only during the sleep phase (time-restricted lithogenic diet feeding, TRF) or an LD Results: TRF caused a dysregulation of the circadian rhythm in the mice, characterized by significant differences in the circadian expression patterns of clock-related genes. In TRF mice, the circadian rhythms in the expression of genes involved in bile acid and cholesterol metabolism were disrupted, as was the circadian rhythm of the gut microbiota. These changes were associated with high biliary cholesterol content, which promoted gallstone formation in the TRF mice. Conclusion: Disordered circadian rhythm is associated with abnormal hepatic bile acid and cholesterol metabolism in mice, which promotes gallstone formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.