Evidence map›Paper›PMID 34744970›Full record

ArticleFrontiers in neurology2021

Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of

Qiancheng Mu, Yuxuan Zhang, Long Gu, Stefan T Gerner, Xiancheng Qiu, Qianke Tao, Jinwei Pang, Ghosh Dipritu, Lifang Zhang, Shigang Yin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Qiancheng MuDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yuxuan ZhangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Long GuLuzhou Key Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Stefan T GernerDepartment of Neurology, University Hospital Erlangen-Nuremberg, Erlangen, Germany.
Xiancheng QiuDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Qianke TaoDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jinwei PangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Ghosh DiprituDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Lifang ZhangLuzhou Key Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Shigang YinLuzhou Key Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yong JiangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jianhua PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CNUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial hypertension is considered the most prevalent risk factor for stroke. Both pathophysiologic and clinical data previously acquired suggest a strong correlation between the hemodynamic nature of arterial hypertension and an increase in the risk of ischemic insult to tissues. However, the knowledge of specific molecular interactions between hypertension and ischemic stroke (IS) is limited. In this study, we performed systematic bioinformatics analysis of stroke-prone spontaneous hypertensive brain tissue samples of rats (GSE41452), middle cerebral artery occlusion of brain tissue samples of rats (GSE97537), and peripheral blood array data of IS patients (GSE22255). We identified that

Indexed as

apoptosisFoshypertensionischemic strokemitochondriaoxidative stressoxygen-glucose deprivation

Identifiers

PMID34744970
PMCPMC8566985
OpenAlexW3208144253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.