Evidence map›Paper›PMID 34744793›Full record

ArticleFrontiers in physiology2021

Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice.

Lawrence E Greiten, Bin Zhang, Carolyn M Roos, Michael Hagler, Fritz-Patrick Jahns, Jordan D Miller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Ginsenoside Rg5 mitigates tenocyte deathJournal of ginseng research · 2026
    Article
  5. Review
  6. Model Systems to Study the Mechanism of Vascular Aging.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lawrence E GreitenDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Bin ZhangDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Carolyn M RoosDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Michael HaglerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Fritz-Patrick JahnsDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Jordan D MillerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Role of SIRT6 in calcific aortic valve diseaseR01HL111121 · NHLBI · MAYO CLINIC ROCHESTER · PI MILLER, JORDAN D · 2013 to 2017
$2.0M
Role of senescent cells in the pathogenesis of Marfan-associated cardiovascular diseaseR01HL141819 · NHLBI · MAYO CLINIC ROCHESTER · PI MILLER, JORDAN D · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL111121NHLBI NIH HHS R01 HL141819
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingendothelial dysfunctionhistone deacetylationsirtuin 6vascular function

Identifiers

PMID34744793
PMCPMC8564013
OpenAlexW3207336316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.