Evidence map›Paper›PMID 34744746›Full record

ArticleFrontiers in pharmacology2021

CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-κB and MAPK Signaling Pathways by Sponging miR-5114.

Mingxin Dong, Xiaohao Zhang, Haotian Yu, Yan Wang, Ying Chang, Chengbiao Sun, Jianxu Zhang, Na Zhao, Kaikai Yu, Guangchao Sun and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Mingxin DongChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Xiaohao ZhangDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Haotian YuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Yan WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Ying ChangJilin Medical University, Jilin, China.
Chengbiao SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Jianxu ZhangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Na ZhaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Kaikai YuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Guangchao SunDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Guiru ZhaoChangchun Vocational Institute of Technology, Changchun, China.
Na XuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Wensen LiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Chinese Academy of Agricultural Sciences · CNJilin Medical University · CNSecond Affiliated Hospital of Jilin University · CNChangchun Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing studies have concentrated on investigating circular RNAs (circRNAs) as pivotal regulators in the progression of numerous diseases and biological processes and abundant evidence shows that circRNAs are participated in the regulation of innate immune responses. Several studies showed that Ricin Toxin (RT) could induce inflammatory injury. There was no research on the particular functions and underlying mechanisms of circRNAs in RT-induced inflammation. In this study, RNA sequencing performed on RT-treated and normal RAW264.7 macrophage cells was used to investigated the differentially expressed circRNAs. Based on the dataset, the expression of circEpc1 (mmu_circ_0,000,842) was identified higher in RT-treated cells. Moreover, gain-and-loss function assays showed that circEpc1 function as a promoter in RT-induced inflammation

Indexed as

circEpc1inflammationNF-κB/MAPKNod2ricin toxin

Identifiers

PMID34744746
PMCPMC8569240
OpenAlexW3194839695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.