Evidence map›Paper›PMID 34744706›Full record

ArticleFrontiers in pharmacology2021

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis.

Habtamu B Derseh, Kopiyawaththage U E Perera, Sasika N Vithana Dewage, Andrew Stent, Emmanuel Koumoundouros, Louise Organ, Charles N Pagel, Ken J Snibson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Habtamu B DersehFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.
Kopiyawaththage U E PereraFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.
Sasika N Vithana DewageFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.
Andrew StentFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, VIC, Australia.
Emmanuel KoumoundourosDepartment of Biomedical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia.
Louise OrganDivision of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom.
Charles N PagelFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.
Ken J SnibsonFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.
University of Melbourne · AUUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by excessive extracellular matrix (ECM) deposition in the parenchyma of the lung. Accompanying the fibrotic remodeling, dysregulated angiogenesis has been observed and implicated in the development and progression of pulmonary fibrosis. Copper is known to be required for key processes involved in fibrosis and angiogenesis. We therefore hypothesized that lowering bioavailable serum copper with tetrathiomolybdate could be of therapeutic value for treating pulmonary fibrosis. This study aimed to investigate the effect of tetrathiomolybdate on angiogenesis and fibrosis induced in sheep lung segments infused with bleomycin. Twenty sheep received two fortnightly infusions of either bleomycin (3U), or saline (control) into two spatially separate lung segments. A week after the final bleomycin/saline infusions, sheep were randomly assigned into two groups (

Indexed as

AngiogenesisBleomycinCopperLarge animal modelPulmonary fibrosisTetrathiomolybdate

Identifiers

PMID34744706
PMCPMC8570673
OpenAlexW3210137914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.