Evidence map›Paper›PMID 34744664›Full record

ArticleFrontiers in human neuroscience2021

Neuromuscular Age-Related Adjustment of Gait When Moving Upwards and Downwards.

Arthur H Dewolf, Francesca Sylos-Labini, Germana Cappellini, Dmitry Zhvansky, Patrick A Willems, Yury Ivanenko, Francesco Lacquaniti

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  6. microPublication biology · 2025
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  12. Left-Right Locomotor Coordination in Human Neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Arthur H DewolfDepartment of Systems Medicine and Center of Space Biomedicine, University of Rome Tor Vergata, Rome, Italy.
Francesca Sylos-LabiniLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Germana CappelliniLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Dmitry ZhvanskyLaboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Moscow, Russia.
Patrick A WillemsLaboratoire de Physiologie et Biomecanique de la Locomotion, Université catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium.
Yury IvanenkoLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Francesco LacquanitiDepartment of Systems Medicine and Center of Space Biomedicine, University of Rome Tor Vergata, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITInstitute for Information Transmission Problems · RUUCLouvain · BEUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Locomotor movements are accommodated to various surface conditions by means of specific locomotor adjustments. This study examined underlying age-related differences in neuromuscular control during level walking and on a positive or negative slope, and during stepping upstairs and downstairs. Ten elderly and eight young adults walked on a treadmill at two different speeds and at three different inclinations (0°, +6°, and -6°). They were also asked to ascend and descend stairs at self-selected speeds. Full body kinematics and surface electromyography of 12 lower-limb muscles were recorded. We compared the intersegmental coordination, muscle activity, and corresponding modifications of spinal motoneuronal output in young and older adults. Despite great similarity between the neuromuscular control of young and older adults, our findings highlight subtle age-related differences in all conditions, potentially reflecting systematic age-related adjustments of the neuromuscular control of locomotion across various support surfaces. The main distinctive feature of walking in older adults is a significantly wider and earlier activation of muscles innervated by the sacral segments. These changes in neuromuscular control are reflected in a reduction or lack of propulsion observed at the end of stance in older adults at different slopes, with the result of a delay in the timing of redirection of the centre-of-mass velocity and of an unanticipated step-to-step transition strategy.

Indexed as

agingcoordinationmuscle activity analysisneuromechanics of gaitspinal motoneuronal outputstair and slope

Identifiers

PMID34744664
PMCPMC8566537
OpenAlexW3208473284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.