ArticleFrontiers in neural circuits2021
Bitbow Enables Highly Efficient Neuronal Lineage Tracing and Morphology Reconstruction in Single
Article in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Heat shock-optimized CRISPR/Cas9 system for visible clonal analysis and mutant generation in Drosophila.G3 (Bethesda, Md.) · 2025Article
- Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes.bioRxiv : the preprint server for biology · 2025Article
- Article
- Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context.bioRxiv : the preprint server for biology · 2025Article
- A parallelly distributed microscope and software system for scalable high-throughput multispectral 3D imaging.bioRxiv : the preprint server for biology · 2025Article
- Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.Current biology : CB · 2023Article
- Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023Article
- Blind demixing methods for recovering dense neuronal morphology from barcode imaging data.PLoS computational biology · 2022Article
- Principles for the design of multicellular engineered living systems.APL bioengineering · 2022Article
- Multicolor strategies for investigating clonal expansion and tissue plasticity.Cellular and molecular life sciences : CMLS · 2022Review
- The molecular landscape of neural differentiation in the developing Drosophila brain revealed by targeted scRNA-seq and multi-informatic analysis.Cell reports · 2021Article
- Towards a Comprehensive Optical Connectome at Single Synapse ResolutionFrontiers in synaptic neuroscience · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Identifying the cellular origins and mapping the dendritic and axonal arbors of neurons have been century old quests to understand the heterogeneity among these brain cells. Current Brainbow based transgenic animals take the advantage of multispectral labeling to differentiate neighboring cells or lineages, however, their applications are limited by the color capacity. To improve the analysis throughput, we designed Bitbow, a digital format of Brainbow which exponentially expands the color palette to provide tens of thousands of spectrally resolved unique labels. We generated transgenic Bitbow
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