Evidence map›Paper›PMID 34744627›Full record

ArticleFrontiers in molecular neuroscience2021

Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens.

Loreto S San Martin, Lorena Armijo-Weingart, Anibal Araya, Gonzalo E Yévenes, Robert J Harvey, Luis G Aguayo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Loreto S San MartinDepartment of Physiology, Programa de Neurociencia, Psiquiatria y Salud Mental, Universidad de Concepción, Concepción, Chile.
Lorena Armijo-WeingartDepartment of Physiology, Programa de Neurociencia, Psiquiatria y Salud Mental, Universidad de Concepción, Concepción, Chile.
Anibal ArayaDepartment of Physiology, Programa de Neurociencia, Psiquiatria y Salud Mental, Universidad de Concepción, Concepción, Chile.
Gonzalo E YévenesDepartment of Physiology, Programa de Neurociencia, Psiquiatria y Salud Mental, Universidad de Concepción, Concepción, Chile.
Robert J HarveySchool of Health and Behavioural Sciences, University of the Sunshine Coast, Sunshine Coast, QLD, Australia.
Luis G AguayoDepartment of Physiology, Programa de Neurociencia, Psiquiatria y Salud Mental, Universidad de Concepción, Concepción, Chile.
University of Concepción · CLUniversity of the Sunshine Coast · AU

Funding

Mechanisms for potentiation of glycine receptors by ethanol.R01AA025718 · NIAAA · UNIVERSITY OF CONCEPCION · PI AGUAYO, LUIS GERARDO · 2017 to 2021
$1.1M
Medical Research Council G0500833NIAAA NIH HHS R01 AA025718
6 · The paper itself

Abstract

The glycine receptor (GlyR), a ligand-gated ion channel, is critical for inhibitory neurotransmission in brainstem, spinal cord, and in supraspinal regions. Recent data from several laboratories have shown that GlyRs are expressed in the brain reward circuitry and that α1 and α2 are the principal subunits expressed in the nucleus accumbens (nAc). In the present study, we studied the sensitivity to ethanol of homomeric and heteromeric α3 GlyR subunits in HEK293 cells and dissociated neurons from the nAc. Finally, we explored ethanol-related behaviors in a

Indexed as

alcohol use disorder (AUD)ethanolglycine receptor (GlyR)nucleus accumbensreward system

Identifiers

PMID34744627
PMCPMC8570041
OpenAlexW3210477925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.