Evidence map›Paper›PMID 34744538›Full record

ArticleAnnals of burns and fire disasters2021

Effective Management Of Topical Nosocomial Aspergillus Spp. Infections In Three Severely Burned Patients.

O Pantet, A Laurent, P Abdel-Sayed, N Hirt-Burri, M Michetti, W Raffoul, M Monod, L A Applegate, A S de Buys Roessingh

Open access · greenAbstract read

In one paragraph

Article in Annals of burns and fire disasters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 87% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

O PantetLausanne University Hospital, University of Lausanne, Switzerland.

A LaurentLausanne University Hospital, University of Lausanne, Switzerland.

P Abdel-SayedLausanne University Hospital, University of Lausanne, Switzerland.

N Hirt-BurriLausanne University Hospital, University of Lausanne, Switzerland.

M MichettiLausanne University Hospital, University of Lausanne, Switzerland.

W RaffoulLausanne University Hospital, University of Lausanne, Switzerland.

M MonodLausanne University Hospital, University of Lausanne, Switzerland.

L A ApplegateLausanne University Hospital, University of Lausanne, Switzerland.

A S de Buys RoessinghLausanne University Hospital, University of Lausanne, Switzerland.

University of Lausanne · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nosocomial opportunistic fungal infections by Aspergillus spp. represent increasing morbidity and mortality factors for severely burned patients, who are fragile and immunocompromised. Voriconazole (VRC), a modern antifungal drug, is used as a first-line therapy against systemic mold and yeast infections. Little has been published about the place, relative importance and efficacy of voriconazole in the treatment protocols involving Aspergillus spp. in Burn Centers. The objective of the present work was to assess the place and importance of voriconazole for the treatment of burn patients presenting superficial Aspergillus spp. infections. We performed a retrospective evaluation of VRC treatment in three severely burned patients with superficial nosocomial Aspergillus spp. infections in our Burn Center. Results showed that VRC allowed for control and cure of topical nosocomial Aspergillus spp. infections. In two cases, treatment with VRC had to be discontinued because of hepatotoxicity. In two cases, following or during systemic treatment with VRC, a 1% terbinafine cream was applied to resolve the infection in order to continue standard wound management. Overall, VRC has been shown to be an effective antifungal agent and is an alternative to amphotericin B to fight Aspergillus spp. infections developing in the wounds of severely burned patients.

Indexed as

antifungalsAspergillusburnsinfectionvoriconazole

Identifiers

PMID34744538

PMCPMC8534306

OpenAlexW3211861975

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.