Evidence map›Paper›PMID 34744104›Full record

ArticleInternal medicine (Tokyo, Japan)2022

The Simultaneous Onset of Pancreatitis and Colitis as Immune-related Adverse Events in a Patient Receiving Nivolumab Treatment for Renal Cell Carcinoma.

Tomotaka Yazaki, Ichiro Moriyama, Hiroshi Tobita, Hiroki Sonoyama, Eiko Okimoto, Akihiko Oka, Yoshiyuki Mishima, Naoki Oshima, Kotaro Shibagaki, Kousaku Kawashima and 5 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Tomotaka YazakiDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Ichiro MoriyamaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Hiroshi TobitaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Hiroki SonoyamaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Eiko OkimotoDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Akihiko OkaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Yoshiyuki MishimaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Naoki OshimaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Kotaro ShibagakiDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Kousaku KawashimaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Norihisa IshimuraDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Taichi NagamiDepartment of Urology, Shimane University Faculty of Medicine, Japan.
Riruke MaruyamaOrgan Pathology Unit, Department of Pathology, Shimane University Faculty of Medicine, Japan.
Hiroaki ShiinaDepartment of Urology, Shimane University Faculty of Medicine, Japan.
Shunji IshiharaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Japan.
Shimane University · JPShimane University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs), which have anti-tumor effects, are currently approved for treatment of several kinds of advanced malignancies. However, with their increasing use, a variety of immune-related adverse events (irAEs) in administered patients have been reported. We herein report a rare case of the simultaneous onset of acute pancreatitis and colitis as irAEs during nivolumab treatment given to a patient with renal cell carcinoma, who then shown marked improvement with corticosteroid therapy.

Indexed as

Carcinoma, Renal CellColitisKidney NeoplasmsPancreatitisAcute DiseaseFemaleHumansMaleNivolumabNivolumabcolitisimmune checkpoint inhibitorimmune-related adverse eventpancreatitis

Identifiers

PMID34744104
PMCPMC9177368
OpenAlexW3214254557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.