ArticleJournal of Alzheimer's disease : JAD2021
The Resilience Index: A Quantifiable Measure of Brain Health and Risk of Cognitive Impairment and Dementia.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Defining and Measuring Cognitive Decline and Clinical Relevance.Neurology and therapy · 2026Review
- Article
- Associations between self-reported change in lifestyle behaviors and brain health: Findings from the Healthy Brain Initiative.Journal of Alzheimer's disease : JAD · 2026Article
- "Brain health"-the emergence of a new healthy construct and its role in everyday life.The Gerontologist · 2026Article
- The heat exposure, aging trajectories, and Alzheimer's disease (HEAT-AD) study protocol.PloS one · 2026Article
- Living in a 20-min neighborhood and brain health and resilience in older adults: The Healthy Brain Initiative.Health & place · 2025Article
- Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2025Article
- DNA methylation signature of a lifestyle-based resilience index for cognitive health.Alzheimer's research & therapy · 2025Article
- Resilience in Alzheimer's disease: Impact of operationalization and methodological choices.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Characterizing the progression from mild cognitive impairment to dementia: a network analysis of longitudinal clinical visits.BMC medical informatics and decision making · 2024Article
- High frequency post-pause word choices and task-dependent speech behavior characterize connected speech in individuals with mild cognitive impairment.medRxiv : the preprint server for health sciences · 2024Article
- Brain health assessment. An exploratory review of tools related to its cognitive dimension.Cerebral circulation - cognition and behavior · 2024Article
- Social Determinants of Health, Risk and Resilience against Alzheimer's Disease and Related Dementias: The Healthy Brain Initiative.Journal of Alzheimer's disease reports · 2024Article
- The Mediating Role of Cortical Atrophy on the Relationship between the Resilience Index and Cognitive Function: Findings from the Healthy Brain Initiative.Journal of Alzheimer's disease : JAD · 2024Article
- Quantitative estimate of cognitive resilience and its medical and genetic associations.Alzheimer's research & therapy · 2023Article
- Article
- Cognitive Resilience in Brain Health and Dementia Research.Journal of Alzheimer's disease : JAD · 2022Review
- The Brain Health Platform: Combining Resilience, Vulnerability, and Performance to Assess Brain Health and Risk of Alzheimer's Disease and Related Disorders.Journal of Alzheimer's disease : JAD · 2022Article
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14 authors.
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Abstract
backgroundThere is increasing interest in lifestyle modification and integrative medicine approaches to treat and/or prevent mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD).
objectiveTo address the need for a quantifiable measure of brain health, we created the Resilience Index (RI).
methodsThis cross-sectional study analyzed 241 participants undergoing a comprehensive evaluation including the Clinical Dementia Rating and neuropsychological testing. Six lifestyle factors including physical activity, cognitive activity, social engagements, dietary patterns, mindfulness, and cognitive reserve were combined to derive the RI (possible range of scores: 1-378). Psychometric properties were determined.
resultsThe participants (39 controls, 75 MCI, 127 ADRD) had a mean age of 74.6±9.5 years and a mean education of 15.8±2.6 years. The mean RI score was 138.2±35.6. The RI provided estimates of resilience across participant characteristics, cognitive staging, and ADRD etiologies. The RI showed moderate-to-strong correlations with clinical and cognitive measures and very good discrimination (AUC: 0.836; 95% CI: 0.774-0.897) between individuals with and without cognitive impairment (diagnostic odds ratio = 8.9). Individuals with high RI scores (> 143) had better cognitive, functional, and behavioral ratings than individuals with low RI scores. Within group analyses supported that controls, MCI, and mild ADRD cases with high RI had better cognitive, functional, and global outcomes than those with low RI.
conclusionThe RI is a brief, easy to administer, score and interpret assessment of brain health that incorporates six modifiable protective factors. Results from the RI could provide clinicians and researchers with a guide to develop personalized prevention plans to support brain health.
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