ArticleJournal of Parkinson's disease2022
Recruitment for Remote Decentralized Studies in Parkinson's Disease.
Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recommendations to promote equity, diversity and inclusion in decentralized clinical trials.Nature medicine · 2024Guideline
- From past to future: Digital approaches to success of clinical drug trials for Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Participation of ethnic minorities in Parkinson's research: challenges and needs. A qualitative study.Age and ageing · 2025Article
- The potential of distributed diagnostics for the early detection of Parkinson's disease.Journal of Parkinson's disease · 2025Review
- Improving recruitment and retention of people with Parkinson's disease to clinical studies: A scoping review.Journal of Parkinson's disease · 2025Article
- Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.Brain : a journal of neurology · 2024Article
- AccessPD as a next generation registry to accelerate Parkinson's disease research.NPJ Parkinson's disease · 2024Article
- Seven Strategies to Integrate Equity within Translational Research in Neurology.Annals of neurology · 2024Review
- Narrative review of telemedicine applications in decentralized research.Journal of clinical and translational science · 2024Review
- Online cognitive testing in Parkinson's disease: advantages and challenges.Frontiers in neurology · 2024Review
- Designing the First Trials for Parkinson's Prevention.Journal of Parkinson's disease · 2024Review
- EFAS/EAN survey on the influence of the COVID-19 pandemic on European clinical autonomic education and research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Digital health technologies and Alzheimer's disease clinical trials: might decentralized clinical trials increase participation by people with cognitive impairment?Alzheimer's research & therapy · 2023Article
- Methods and perceptions of success for patient recruitment in decentralized clinical studies.Journal of clinical and translational science · 2023Review
- Recruitment and Retention in Remote Research: Learnings From a Large, Decentralized Real-world Study.JMIR formative research · 2022Article
- Moving Forward from the COVID-19 Pandemic: Needed Changes in Movement Disorders Care and Research.Current neurology and neuroscience reports · 2022Review
- Parkinson's disease and Covid-19: The effect and use of telemedicine.International review of neurobiology · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundTraditional in-person Parkinson's disease (PD) research studies are often slow to recruit and place unnecessary burden on participants. The ongoing COVID-19 pandemic has added new impetus to the development of new research models.
objectiveTo compare recruitment processes and outcomes of three remote decentralized observational PD studies with video visits.
methodsWe examined the number of participants recruited, speed of recruitment, geographic distribution of participants, and strategies used to enhance recruitment in FIVE, a cross-sectional study of Fox Insight participants with and without PD (n = 203); VALOR-PD, a longitudinal study of 23andMe, Inc. research participants carrying the LRRK2 G2019S variant with and without PD (n = 277); and AT-HOME PD, a longitudinal study of former phase III clinical trial participants with PD (n = 226).
resultsAcross the three studies, 706 participants from 45 U.S. states and Canada enrolled at a mean per study rate of 4.9 participants per week over an average of 51 weeks. The cohorts were demographically homogenous with regard to race (over 95%white) and level of education (over 90%with more than a high school education). The number of participants living in primary care Health Professional Shortage Areas in each study ranged from 30.3-42.9%. Participants reported interest in future observational (98.5-99.6%) and interventional (76.1-87.6%) research studies with remote video visits.
conclusionRecruitment of large, geographically dispersed remote cohorts from a single location is feasible. Interest in participation in future remote decentralized PD studies is high. More work is needed to identify best practices for recruitment, particularly of diverse participants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.