ArticleAdvances in rheumatology (London, England)2021
Neuropathic pain in knee osteoarthritis.
Article in Advances in rheumatology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Systematic review of repetitive transcranial magnetic stimulation for post-stroke hemiplegic shoulder pain.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Pooled it
- Trial
- Neuropathic-like pain in knee osteoarthritis: exploring differences in knee loading and inflammation. A cross-sectional study.European journal of physical and rehabilitation medicine · 2024Trial
- DN4-Positive Neuropathic Pain Features in End-Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality-of-Life.International journal of rheumatic diseases · 2026Article
- Frequency and factors associated with neuropathic pain in patients with knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Mechanistic Pathways Linking Type 2 Diabetes Mellitus, Hypertension, and Osteoarthritis to Falls in Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee.Osteoarthritis and cartilage open · 2026Article
- Photobiomodulation for the treatment of knee osteoarthritis: therapeutic effects and molecular mechanism.Frontiers in cell and developmental biology · 2026Review
- Neuropathic pain in knee osteoarthritis: functional burden beyond cartilage thickness-a cross-sectional study.BMC research notes · 2025Article
- Factors Associated With the Risk of Neuropathic Pain One Year After Total Knee Arthroplasty and the Protective Role of Local Infiltration Analgesia: A Registry-Based Prospective Cohort Study.ACR open rheumatology · 2025Article
- De novo post-COVID-19 chronic pain: a piece of information about risk factor and clinical features.Pain reports · 2025Article
- Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences, and Future Directions.Journal of clinical medicine · 2025Review
- Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.Heliyon · 2025Review
- Article
- Neuropathic pain in knee osteoarthritis: Prevalence, diagnosis, and clinical implications.Joint diseases and related surgery · 2025Article
- Vitamin D deficiency and neuropathic pain in chronic spinal cord injury: a cross-sectional study.Frontiers in nutrition · 2025Article
- Integrating nociplastic pain into neuropathic pain framework: a proposal for a revised classification.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- The role of obesity and adipose tissue dysfunction in osteoarthritis pain.Nature reviews. Rheumatology · 2024Review
- A Review of Current Approaches to Pain Management in Knee Osteoarthritis with a Focus on Italian Clinical Landscape.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the relationship between the neuropathic pain in knee osteoarthritis with the body composition, anthropometric and postural features, physical function, and quality of life.
methodsPatients with primary knee osteoarthritis, 50-70 years of age, were included in the study and divided into Group 1 with neuropathic pain and Group 2 with no neuropathic pain according to Douleur Neuropathique-4. The groups were compared in terms of demographic, clinical, radiological, laboratory findings and anthropometric measurements, body composition, physical function tests, osteoarthritis severity, quality of life, and posturography.
results200 patients were included in the study. 98 (82.6% female) were in Group 1 and 102 (74.5% female) in Group 2. Age was higher in Group 1 compared to Group 2 [61 (50-70) and 57.5 (50-70), respectively, p = 0.03]. Symptom duration was also longer in Group 1 (5.21 ± 4.76 and 3.38 ± 3.58, p = 0.002). Body mass indices were 31.9 ± 5.6 and 30.1 ± 4.8 (p = 0.015). Kellgren-Lawrence class, Western Ontario and McMaster Osteoarthritis Index and Short Form-36 scores were more unfavorable in Group 1. Although fall risk was similar, stability and Fourier harmony indices were impaired in Group 1 compared to Group 2 especially when the visual and proprioceptive input was blocked.
conclusionsAlmost half of the patients with knee osteoarthritis had neuropathic pain which was associated with longer symptom duration and higher age, lower education, higher body mass index, more severe radilogical findings, worse pain perception, lower physical function and quality of life, and lower stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.